Morón-Ortiz Ángeles, Karamalegkos Antonis A, Mapelli-Brahm Paula, Ezcurra Marina, Meléndez-Martínez Antonio J
Food Colour and Quality Laboratory, Facultad de Farmacia, Universidad de Sevilla, 41012 Sevilla, Spain.
School of Biosciences, University of Kent, Canterbury CT2 7NJ, UK.
Antioxidants (Basel). 2024 Jul 31;13(8):931. doi: 10.3390/antiox13080931.
Phytoene is a colourless carotenoid widely available from dietary sources and a precursor for the synthesis of other carotenoids. Although present at high concentrations across different tissues, phytoene is largely viewed as not having physiological activity. Here, we utilize the model organism to show that phytoene is bioactive and has anti-ageing properties. Supplementation with phytoene protects against oxidative damage and amyloid-β proteotoxicity (a major pathology of Alzheimer's disease), and extends lifespan. We also examine extracts from two microalgae, and . We show that the extracts contain high levels of phytoene, and find that these phytoene-rich extracts have protective effects similar to pure phytoene. Our findings show that phytoene is a bioactive molecule with positive effects on ageing and longevity. Our work also suggests that phytoene-rich microalgae extracts can utilized to produce foods or supplements that promote healthy ageing and prevent the development of chronic age-related diseases.
八氢番茄红素是一种无色类胡萝卜素，在饮食来源中广泛存在，是合成其他类胡萝卜素的前体。尽管八氢番茄红素在不同组织中含量很高，但人们普遍认为它没有生理活性。在这里，我们利用模式生物表明八氢番茄红素具有生物活性和抗衰老特性。补充八氢番茄红素可防止氧化损伤和β-淀粉样蛋白的蛋白毒性（阿尔茨海默病的主要病理学特征），并延长寿命。我们还研究了两种微藻的提取物。我们表明这些提取物含有高水平的八氢番茄红素，并发现这些富含八氢番茄红素的提取物具有与纯八氢番茄红素相似的保护作用。我们的研究结果表明，八氢番茄红素是一种对衰老和长寿有积极影响的生物活性分子。我们的工作还表明，富含八氢番茄红素的微藻提取物可用于生产促进健康衰老和预防与年龄相关的慢性疾病发展的食品或补充剂。
