Dubé D, Pelletier G
J Histochem Cytochem. 1979 Dec;27(12):1577-81. doi: 10.1177/27.12.391994.
Somatostatin (SRIF), the hypothalmic hormone which inhibits the secretion of growth hormone by the pituitary, has been localized immunohistochemically in the rat hypothalamus after intracerebral injection of colchicine. The number of cell bodies staining for SRIF was increased in the periventricular nucleus while the number of nerve fibers was decreased in the median eminence after treatment. The number of secretory granules containing SRIF in the nerve cell bodies was increased in the treated animals, suggesting a correlation between the number of specific secretory granules and intensity of the immunohistochemical reaction. These observations are in agreement with the hypothesis that SRIF cell bodies in the periventricular nucleus send their axons into the median eminence.
生长抑素（SRIF）是一种下丘脑激素，可抑制垂体分泌生长激素。在脑室内注射秋水仙碱后，已通过免疫组织化学方法在大鼠下丘脑定位了生长抑素。处理后，室旁核中对SRIF染色的细胞体数量增加，而正中隆起中的神经纤维数量减少。在处理过的动物中，神经细胞体中含有SRIF的分泌颗粒数量增加，这表明特定分泌颗粒的数量与免疫组织化学反应强度之间存在相关性。这些观察结果与室旁核中的SRIF细胞体将其轴突发送到正中隆起的假设一致。
