• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

癫痫的病理生理学与治疗方法的最新进展

Recent Advances in Pathophysiology and Therapeutic Approaches in Epilepsy.

作者信息

Prakash Chandra, Kumar Pavan, Sharma Deepak

机构信息

Neurobiology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi 110067, India.

Department of Anatomy and Cell Biology, College of Medicine, The University of Illinois at Chicago, Chicago, IL 60607, USA.

出版信息

Brain Sci. 2024 Aug 2;14(8):785. doi: 10.3390/brainsci14080785.

DOI:10.3390/brainsci14080785
PMID:39199478
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11353141/
Abstract

Epilepsy is a severe neurological disorder involving spontaneous and recurrent seizures, affecting a large number of people worldwide [...].

摘要

癫痫是一种严重的神经系统疾病，涉及自发性和复发性癫痫发作，影响着全球大量人口。[...]

相似文献

1
Recent Advances in Pathophysiology and Therapeutic Approaches in Epilepsy.癫痫的病理生理学与治疗方法的最新进展
Brain Sci. 2024 Aug 2;14(8):785. doi: 10.3390/brainsci14080785.
2
Advances in the Potential Biomarkers of Epilepsy.癫痫潜在生物标志物的研究进展
Front Neurol. 2019 Jul 2;10:685. doi: 10.3389/fneur.2019.00685. eCollection 2019.
3
Precision medicine in epilepsy.癫痫精准医学。
Prog Mol Biol Transl Sci. 2022;190(1):147-188. doi: 10.1016/bs.pmbts.2022.04.001. Epub 2022 May 23.
4
Adrenergic receptor system as a pharmacological target in the treatment of epilepsy (Review).肾上腺素能受体系统作为癫痫治疗的药理学靶点（综述）。
Med Int (Lond). 2024 Feb 27;4(2):20. doi: 10.3892/mi.2024.144. eCollection 2024 Mar-Apr.
5
Envisioning the role of inwardly rectifying potassium (Kir) channel in epilepsy.想象内向整流钾（Kir）通道在癫痫中的作用。
J Neurosci Res. 2022 Feb;100(2):413-443. doi: 10.1002/jnr.24985. Epub 2021 Oct 29.
6
Antagonizing Increased Levels at the Chronic Stage of Experimental TLE Reduces Spontaneous Recurrent Seizures.拮抗实验性颞叶癫痫慢性期的升高水平可减少自发性复发癫痫。
J Neurosci. 2019 Jun 26;39(26):5064-5079. doi: 10.1523/JNEUROSCI.3014-18.2019. Epub 2019 Apr 23.
7
Opportunities and challenges for microRNA-targeting therapeutics for epilepsy.癫痫的 microRNA 靶向治疗的机遇与挑战。
Trends Pharmacol Sci. 2021 Jul;42(7):605-616. doi: 10.1016/j.tips.2021.04.007. Epub 2021 May 12.
8
Eight Flurothyl-Induced Generalized Seizures Lead to the Rapid Evolution of Spontaneous Seizures in Mice: A Model of Epileptogenesis with Seizure Remission.八氟乙烷诱发的全身性癫痫发作导致小鼠自发性癫痫发作的快速演变：一种伴有癫痫发作缓解的癫痫发生模型。
J Neurosci. 2016 Jul 13;36(28):7485-96. doi: 10.1523/JNEUROSCI.3232-14.2016.
9
Models and detection of spontaneous recurrent seizures in laboratory rodents.实验室啮齿动物自发性复发性癫痫的模型与检测。
Zool Res. 2017 Jul 18;38(4):171-179. doi: 10.24272/j.issn.2095-8137.2017.042.
10
Novel therapeutic targets for epilepsy intervention.癫痫干预的新治疗靶点。
Seizure. 2017 Oct;51:27-34. doi: 10.1016/j.seizure.2017.07.014. Epub 2017 Jul 25.

引用本文的文献

1
Epileptic seizure biophysics: the role of local voltage difference.癫痫发作生物物理学：局部电压差的作用。
Mil Med Res. 2025 Jul 11;12(1):35. doi: 10.1186/s40779-025-00620-4.
2
Self-Supervised Learning with Adaptive Frequency-Time Attention Transformer for Seizure Prediction and Classification.基于自适应频率-时间注意力变换器的自监督学习用于癫痫发作预测与分类
Brain Sci. 2025 Apr 7;15(4):382. doi: 10.3390/brainsci15040382.

本文引用的文献

1
Adverse Event Profiles of Antiseizure Medications and the Impact of Coadministration on Drug Tolerability in Adults with Epilepsy.抗癫痫药物的不良反应谱及在成人癫痫患者中合并用药对药物耐受性的影响。
CNS Drugs. 2023 Jun;37(6):531-544. doi: 10.1007/s40263-023-01013-8. Epub 2023 Jun 4.
2
Epileptic-network-based prediction and control of seizures in humans.基于癫痫网络的人类癫痫发作预测与控制。
Neurobiol Dis. 2023 Jun 1;181:106098. doi: 10.1016/j.nbd.2023.106098. Epub 2023 Mar 29.
3
Neurocognitive and psychological comorbidities in patients with self-limited centrotemporal spike epilepsy. A case-control study.局限性中央颞区棘波癫癎患者的神经认知和心理共病。一项病例对照研究。
Rev Neurol. 2023 Mar 1;76(5):153-158. doi: 10.33588/rn.7605.2022385.
4
Relationship between brain activity, cognitive function, and sleep spiking activation in new-onset self-limited epilepsy with centrotemporal spikes.伴有中央颞区棘波的新发自限性癫痫患者的脑活动、认知功能与睡眠棘波激活之间的关系
Front Neurol. 2022 Nov 9;13:956838. doi: 10.3389/fneur.2022.956838. eCollection 2022.
5
Evaluation and management of drug resistant epilepsy in children.儿童耐药性癫痫的评估和管理。
Curr Probl Pediatr Adolesc Health Care. 2021 Jul;51(7):101035. doi: 10.1016/j.cppeds.2021.101035. Epub 2021 Jul 23.
6
Enlightening the neuroprotective effect of quercetin in epilepsy: From mechanism to therapeutic opportunities.揭示槲皮素在癫痫中的神经保护作用：从机制到治疗机会。
Epilepsy Behav. 2021 Feb;115:107701. doi: 10.1016/j.yebeh.2020.107701. Epub 2021 Jan 4.
7
Response of Voltage-Gated Sodium and Calcium Channels Subtypes on Dehydroepiandrosterone Treatment in Iron-Induced Epilepsy.铁诱导癫痫中脱氢表雄酮治疗对电压门控钠和钙通道亚型的反应。
Cell Mol Neurobiol. 2021 Mar;41(2):279-292. doi: 10.1007/s10571-020-00851-0. Epub 2020 Apr 21.
8
Daytime-restricted feeding modulates the expression of inflammatory mediators and diminishes reactive astrogliosis and microgliosis following status epilepticus.限时进食可调节炎症介质的表达，并减轻癫痫持续状态后的反应性星形胶质细胞增生和小胶质细胞增生。
Brain Res. 2020 May 1;1734:146724. doi: 10.1016/j.brainres.2020.146724. Epub 2020 Feb 11.
9
Management of status epilepticus in adults. Position paper of the Italian League against Epilepsy.成人癫痫持续状态的管理。意大利抗癫痫联盟立场文件。
Epilepsy Behav. 2020 Jan;102:106675. doi: 10.1016/j.yebeh.2019.106675. Epub 2019 Nov 22.
10
Surgical Anatomy of Vertical Perithalamic Hemispherotomy.垂直丘脑周围大脑半球切开术的手术解剖学
Oper Neurosurg (Hagerstown). 2020 May 1;18(5):511-517. doi: 10.1093/ons/opz214.