Huljev Frkovic Sanda, Jelusic Marija, Crkvenac Gornik Kristina, Rogic Dunja, Frkovic Marijan
Department of Paediatrics, University Hospital Centre Zagreb, University of Zagreb School of Medicine, 10000 Zagreb, Croatia.
Department of Laboratory Diagnostics, University Hospital Centre Zagreb, 10000 Zagreb, Croatia.
Biomedicines. 2024 Jul 24;12(8):1642. doi: 10.3390/biomedicines12081642.
Because of the unpredictable efficacy of methotrexate (MTX) in the treatment of juvenile idiopathic arthritis (JIA), the possibility of a favourable outcome is reduced in more than 30% of patients. To investigate the possible influence of glutathione S-transferase M1 (GSTM1) and T1 (GSTT1) gene deletion polymorphisms on MTX efficacy in patients with JIA, we determined these polymorphisms in 63 patients with JIA who did not achieve remission and 46 patients with JIA who achieved remission during MTX therapy. No significant differences were observed in the distribution of single GSTM1 or GSTT1 deletion polymorphisms or their combination between the two groups: 58.7% to 63.5%; = 0.567, 17.4% to 22.2%; = 0.502, and 13% to 12.7%; = 0.966, respectively. Our results suggest that GSTM1 and GSTT1 deletion polymorphisms do not influence the efficacy of MTX in patients with JIA. Additional studies are required to determine the possible influence of GST deletion polymorphisms on MTX efficacy in patients with JIA.
由于甲氨蝶呤（MTX）治疗幼年特发性关节炎（JIA）的疗效不可预测，超过30%的患者获得良好预后的可能性降低。为了研究谷胱甘肽S-转移酶M1（GSTM1）和T1（GSTT1）基因缺失多态性对JIA患者MTX疗效的可能影响，我们测定了63例MTX治疗期间未缓解的JIA患者和46例MTX治疗期间缓解的JIA患者的这些多态性。两组间单个GSTM1或GSTT1缺失多态性及其组合的分布无显著差异：分别为58.7%至63.5%；P = 0.567，17.4%至22.2%；P = 0.502，以及13%至12.7%；P = 0.966。我们的结果表明，GSTM1和GSTT1缺失多态性不影响MTX对JIA患者的疗效。需要进一步研究以确定GST缺失多态性对JIA患者MTX疗效的可能影响。
