Sheptulina Anna F, Yafarova Adel A, Mamutova Elvira M, Drapkina Oxana M
Department of Fundamental and Applied Aspects of Obesity, National Medical Research Center for Therapy and Preventive Medicine, Moscow 101990, Russia.
Department of Therapy and Preventive Medicine, A.I. Evdokimov Moscow State University of Medicine and Dentistry, Moscow 127473, Russia.
Biomedicines. 2024 Jul 28;12(8):1684. doi: 10.3390/biomedicines12081684.
This study aimed to describe sonographic features of rectus femoris muscle (RFM) in patients with metabolic dysfunction-associated fatty liver disease (MASLD) and their correlation with body composition parameters and muscle strength. A total of 67 patients with MASLD underwent dual-energy X-ray absorptiometry (DEXA), bioimpedance analysis (BIA), muscle strength measurement (grip strength [GS] and chair stand test [CST]), and ultrasound (US) investigation of the RFM in the dominant thigh using a 4 to 18 MHz linear probe. MASLD patients exhibited increased RFM echogenicity, possibly due to fatty infiltration. We confirmed that the greater the subcutaneous fat thickness, the smaller was the muscle mass ( < 0.001), and the lower was the muscle strength ( < 0.001 for GS and = 0.002 for CST). On the contrary, the greater the anteroposterior diameter (APD) of RFM, the higher was the muscle mass ( < 0.001), and the greater was the muscle strength ( < 0.001 for GS and = 0.007 for CST). In addition, APD of the RFM and stiffness of RFM exhibited direct correlation with bone mineral density values of the lumbar spine ( = 0.005 for both GS and CST). We concluded that US investigation of the RFM in the dominant thigh can be helpful in identifying MASLD patients at a high risk of musculoskeletal disorders given repeated point-of-care clinical evaluations.
本研究旨在描述代谢功能障碍相关脂肪性肝病（MASLD）患者股直肌（RFM）的超声特征，及其与身体成分参数和肌肉力量的相关性。共有67例MASLD患者接受了双能X线吸收法（DEXA）、生物电阻抗分析（BIA）、肌肉力量测量（握力[GS]和椅子站立试验[CST]），并使用4至18MHz线性探头对优势大腿的RFM进行了超声（US）检查。MASLD患者的RFM回声增强，可能是由于脂肪浸润所致。我们证实，皮下脂肪厚度越大，肌肉质量越小（<0.001），肌肉力量越低（GS<0.001，CST=0.002）。相反，RFM的前后径（APD）越大，肌肉质量越高（<0.001），肌肉力量越大（GS<0.001，CST=0.007）。此外，RFM的APD和RFM的硬度与腰椎骨密度值呈直接相关（GS和CST均为=0.005）。我们得出结论，鉴于重复的即时临床评估，对优势大腿的RFM进行超声检查有助于识别有肌肉骨骼疾病高风险的MASLD患者。
