Coppola Gaetano, Principessa Chiara, Di Vincenzo Federica, Puca Pierluigi, Del Gaudio Angelo, Capobianco Ivan, Bartocci Bianca, Papa Alfredo, Cammarota Giovanni, Lopetuso Loris Riccardo, Scaldaferri Franco
CEMAD-IBD Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Rome, Italy.
Dipartimento Universitario di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.
J Clin Med. 2024 Aug 16;13(16):4842. doi: 10.3390/jcm13164842.
Crohn's disease (CD) is a chronic inflammatory disease associated with a significant burden in terms of quality of life and health care costs. It is frequently associated with several complications, including the development of intestinal strictures. Stricturing CD requires a careful multidisciplinary approach involving medical therapy and surgery, still posing a continuous management challenge; in this context, endoscopic treatment represents a valuable, in-between opportunity as a minimally invasive strategy endorsed by extensive yet heterogeneous evidence and evolving research and techniques. This review summarizes current knowledge on the role of therapeutic endoscopy in stricturing CD, focusing on evidence gaps, recent updates, and novel techniques intended for optimizing efficacy, safety, and tailoring of this approach in the view of precision endoscopy.
克罗恩病（CD）是一种慢性炎症性疾病，在生活质量和医疗费用方面造成了重大负担。它常伴有多种并发症，包括肠道狭窄的形成。狭窄性克罗恩病需要一种谨慎的多学科方法，涉及药物治疗和手术，这仍然构成持续的管理挑战；在此背景下，内镜治疗作为一种微创策略，是一个有价值的中间选择，有广泛但参差不齐的证据以及不断发展的研究和技术支持。本综述总结了关于治疗性内镜在狭窄性克罗恩病中作用的当前知识，重点关注证据空白、最新进展以及旨在从精准内镜角度优化该方法的疗效、安全性和个性化的新技术。
