接受口服乳糖酶治疗的婴儿应避免使用西甲硅油药物。
Simethicone Medication Should Be Avoided in Infants Receiving Oral Lactase Treatment.
作者信息
Yildirim Ekin Say, Aydin Adem, Ince Tolga, Varol Zeynep, Ünal Belgin, Demir And
机构信息
Department of Pediatrics, Faculty of Medicine, Dokuz Eylül University, 35340 İzmir, Türkiye.
Department of Public Health, Faculty of Medicine, Dokuz Eylül University, 35340 İzmir, Türkiye.
出版信息
Children (Basel). 2024 Aug 17;11(8):1009. doi: 10.3390/children11081009.
OBJECTIVE
In this retrospective study, we assessed the efficacy of oral lactase in infants with lactose intolerance in terms of sex, birth weight, and interference by other medications.
METHODS
The study was conducted on patients aged 0-6 months who had been diagnosed with lactose intolerance on admission to the Department of Social Pediatrics at Dokuz Eylul University. Demographic data, the onset of symptoms, and medications used were recorded.
RESULTS
We found that 86.7% of the infants responded to lactase, with no significant differences based on sex, birth weight, or age at symptom presentation. We observed, however, that the efficacy of treatment did improve over time, thereby deriving benefits from intestinal development and adaptation. Interestingly, the response to lactase was reduced in infants receiving concomitant simethicone for colic symptoms, suggesting a potential drug interaction, while probiotics had no impact on treatment outcomes.
CONCLUSIONS
We advise against using additional medications with oral lactase, pointing out a possible interaction with simethicone that might decrease the effectiveness of treatment.
目的
在这项回顾性研究中，我们从性别、出生体重以及其他药物的干扰方面评估了口服乳糖酶对乳糖不耐受婴儿的疗效。
方法
该研究针对在多库兹艾吕尔大学社会儿科学系入院时被诊断为乳糖不耐受的0至6个月大的患者进行。记录人口统计学数据、症状出现时间以及使用的药物。
结果
我们发现86.7%的婴儿对乳糖酶有反应，在性别、出生体重或症状出现时的年龄方面无显著差异。然而，我们观察到治疗效果确实会随着时间推移而改善，从而从肠道发育和适应中获益。有趣的是，因腹绞痛症状同时接受西甲硅油治疗的婴儿对乳糖酶的反应降低，这表明可能存在药物相互作用，而益生菌对治疗结果没有影响。
结论
我们建议不要将其他药物与口服乳糖酶一起使用，指出它与西甲硅油可能存在相互作用，这可能会降低治疗效果。
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