Andor Minodora, Dehelean Liana, Arnăutu Diana Aurora, Neagu Marioara Nicula, Nistor Daciana, Manea Minodora Marinela, Romosan Ana-Maria, Kundnani Nilima Rajpal
Medical Semiology II, Internal Medicine I Department, "Victor Babeş" University of Medicine and Pharmacy, 2 E. Murgu Square, 300041 Timişoara, Romania.
Multidisciplinary Heart Research Centre, "Victor Babeş" University of Medicine and Pharmacy, 2 E. Murgu Square, 300041 Timişoara, Romania.
J Pers Med. 2024 Jul 31;14(8):814. doi: 10.3390/jpm14080814.
Schizophrenia is one of the most disabling of the psychiatric diseases. The Brief Psychiatric Rating Scale Extended (BRSE) is used to evaluate the severity of psychiatric symptoms. Long-acting injectable (LAI) antipsychotics are commonly used and are preferred over oral antipsychotic medications. A two-center-based cross-sectional study was performed on 130 patients diagnosed with schizophrenia or schizoaffective disorder based on the International Classification of Diseases 10 criteria. We studied the relation between the development of cardiovascular risk factors and the antipsychotic medication that was administered in these patients. Our study demonstrates strong links between several cardiovascular risk factors and the duration of psychosis; the duration of the LAI antipsychotic treatment; the duration between the onset of the disease and the start of LAI antipsychotic treatment; and the use of specific LAI antipsychotic medications.
精神分裂症是最致残的精神疾病之一。简明精神病评定量表扩展版（BRSE）用于评估精神症状的严重程度。长效注射用抗精神病药物被广泛使用，且比口服抗精神病药物更受青睐。一项基于两个中心的横断面研究对130例根据国际疾病分类第10版标准诊断为精神分裂症或分裂情感性障碍的患者进行了研究。我们研究了这些患者心血管危险因素的发生与所使用的抗精神病药物之间的关系。我们的研究表明，几种心血管危险因素与精神病持续时间、长效注射用抗精神病药物治疗持续时间、疾病发作与开始长效注射用抗精神病药物治疗之间的时间间隔以及特定长效注射用抗精神病药物的使用之间存在密切联系。
