Kutu Funda Canpolat, Özdolap Şenay, Sarikaya Selda
Department of Physical Medicine and Rehabilitation, Çaycuma State Hospital, Zonguldak, Turkey.
Department of Physical Medicine and Rehabilitation, Medicine Faculty of Bülent Ecevit University, Zonguldak, Turkey.
Arch Rheumatol. 2018 Aug 16;34(2):123-129. doi: 10.5606/ArchRheumatol.2019.6733. eCollection 2019 Jun.
This study aims to evaluate the differences in serum levels of tumor necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β), (IL-8), and oxidized low-density lipoprotein (Ox-LDL) between female fibromyalgia (FM) patients and healthy females and also to examine a possible relationship between the cytokines/biomarker and the severity of pain and clinical features of FM.
This case-control study included 48 female patients (mean age 26.51±6.98 years; range, 18 to 50 years) who were diagnosed with FM according to the American College of Rheumatology criteria and 43 healthy female subjects (mean age 23.93±4.22 years; range, 18 to 50 years). Serum levels of TNF-α, IL-1β, IL-8, and Ox-LDL were measured by enzyme-linked immunosorbent assay in both groups. Fibromyalgia Impact Questionnaire, Visual Analog Scale, symptom severity scale, and widespread pain index were carried out and also their relationships with TNF-α, IL-1β, IL-8, and Ox-LDL levels were evaluated.
There was no difference in levels of the serum TNF-α, IL-1β, IL-8, and Ox-LDL between FM patients and healthy controls (p>0.05). The severity of pain was significantly associated with TNF-α (r=0.338; p=0.021) and IL-8 (r=0.299; p=0.043) levels, and Ox-LDL (r=0.415; p=0.006) level was found to be related to symptom severity of FM.
Our results suggest that serum levels of TNF-α and IL-8 may be involved in the occurrence of pain in FM. The level of Ox-LDL may play an important role in the severity of symptoms. Future studies are needed to determine whether and how Ox-LDL plays a role in FM.
本研究旨在评估女性纤维肌痛（FM）患者与健康女性之间血清肿瘤坏死因子-α（TNF-α）、白细胞介素-1β（IL-1β）、白细胞介素-8（IL-8）和氧化型低密度脂蛋白（Ox-LDL）水平的差异，并探讨细胞因子/生物标志物与FM疼痛严重程度及临床特征之间的可能关系。
本病例对照研究纳入了48例根据美国风湿病学会标准诊断为FM的女性患者（平均年龄26.51±6.98岁；范围18至50岁）和43例健康女性受试者（平均年龄23.93±4.22岁；范围18至50岁）。两组均采用酶联免疫吸附测定法检测血清TNF-α、IL-1β、IL-8和Ox-LDL水平。进行了纤维肌痛影响问卷、视觉模拟评分、症状严重程度量表和广泛性疼痛指数评估，并评估了它们与TNF-α、IL-1β、IL-8和Ox-LDL水平的关系。
FM患者与健康对照者之间血清TNF-α、IL-1β、IL-8和Ox-LDL水平无差异（p>0.05）。疼痛严重程度与TNF-α（r=0.338；p=0.021）和IL-8（r=0.299；p=0.043）水平显著相关，且发现Ox-LDL（r=0.415；p=0.006）水平与FM症状严重程度相关。
我们的结果表明，血清TNF-α和IL-8水平可能参与FM疼痛的发生。Ox-LDL水平可能在症状严重程度中起重要作用。未来需要进一步研究以确定Ox-LDL是否以及如何在FM中发挥作用。
