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墨西哥唇腭裂风险因素的发生率：一项系统综述。

The Frequency of Risk Factors for Cleft Lip and Palate in Mexico: A Systematic Review.

作者信息

López-Verdín Sandra, Solorzano-López Judith A, Bologna-Molina Ronell, Molina-Frechero Nelly, Tremillo-Maldonado Omar, Toral-Rizo Victor H, González-González Rogelio

机构信息

Health Science Center, Research Institute of Dentistry, Universidad de Guadalajara, Guadalajara 44100, Mexico.

Molecular Pathology Area, School of Dentistry, Universidad de la República, Montevideo 11400, Uruguay.

出版信息

Diagnostics (Basel). 2024 Aug 12;14(16):1753. doi: 10.3390/diagnostics14161753.

DOI:10.3390/diagnostics14161753
PMID:39202241
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11354172/
Abstract

BACKGROUND

Cleft lip and palate is an anomaly that affects both women and men. It is considered to be among the most frequent congenital abnormalities and is related to modifications in chromosomal DNA and multiple genetic alterations. This anomaly can also be associated with various environmental factors, such as tobacco and alcohol consumption, medication use, and exposure to different environmental and industrial toxic substances. The objective of this study was to document the frequency of risk factors related to cleft lip and palate through a systematic review of Mexican studies.

METHODS

In this systematic review, a bibliographic search was conducted following PRISMA guidelines in the databases Scielo, ScienceDirect, PubMed, and EBSCO. Keywords related to cleft lip and palate, epidemiology, and risk factors were used. In all, 3 independent reviewers (J.A.S.L., S.L.V., and N.M.F.) selected and evaluated a total of 17 articles included in this analysis, achieving a coefficient of κ = 0.84.

RESULTS

The analysis revealed that the highest frequency of conducted studies was in the State of Mexico. The most common risk factors identified were environmental, pharmacological, consumption habits, and gynecological factors.

CONCLUSIONS

Identifying the main risk factors for cleft lip and palate in the Mexican population will enable the implementation of preventive measures aimed at reducing exposure to these factors. Additionally, early intervention can improve the quality of life for individuals affected by this condition.

摘要

背景

唇腭裂是一种影响男性和女性的异常情况。它被认为是最常见的先天性畸形之一，与染色体DNA的改变和多种基因变化有关。这种异常情况还可能与各种环境因素有关，如吸烟、饮酒、用药以及接触不同的环境和工业有毒物质。本研究的目的是通过对墨西哥研究的系统评价，记录与唇腭裂相关的危险因素的频率。

方法

在本系统评价中，按照PRISMA指南在Scielo、ScienceDirect、PubMed和EBSCO数据库中进行文献检索。使用了与唇腭裂、流行病学和危险因素相关的关键词。总共3名独立评审员（J.A.S.L.、S.L.V.和N.M.F.）选择并评估了本分析中纳入的17篇文章，κ系数为0.84。

结果

分析显示，开展研究频率最高的是墨西哥州。确定的最常见危险因素是环境、药理学、消费习惯和妇科因素。

结论

确定墨西哥人群中唇腭裂的主要危险因素将有助于实施旨在减少接触这些因素的预防措施。此外，早期干预可以改善受这种疾病影响的个体的生活质量。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92b6/11354172/12229b2a17c1/diagnostics-14-01753-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92b6/11354172/68f75c6c1c80/diagnostics-14-01753-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92b6/11354172/12229b2a17c1/diagnostics-14-01753-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92b6/11354172/68f75c6c1c80/diagnostics-14-01753-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92b6/11354172/4ea665a94800/diagnostics-14-01753-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/92b6/11354172/0adf5b3db6db/diagnostics-14-01753-g003.jpg
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本文引用的文献

1
Orofacial Clefts: Genetics of Cleft Lip and Palate.口腔颌面部裂隙：唇腭裂的遗传学。
Genes (Basel). 2023 Aug 9;14(8):1603. doi: 10.3390/genes14081603.
2
Characterization of 554 Mexican Patients With Nonsyndromic Cleft Lip and Palate: Descriptive Study.554 例非综合征性唇腭裂墨西哥患者的特征：描述性研究。
J Craniofac Surg. 2023 Sep 1;34(6):1776-1779. doi: 10.1097/SCS.0000000000009455. Epub 2023 Jun 5.
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Trends in Cleft lip and/or Palate Prevalence at Birth in Mexico: A National (Ecological) Study Between 2003 and 2019.
墨西哥先天性唇腭裂患病率的变化趋势：2003 年至 2019 年的全国（生态学）研究。
Cleft Palate Craniofac J. 2023 Nov;60(11):1353-1358. doi: 10.1177/10556656221106881. Epub 2022 Jun 6.
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Non-syndromic Cleft Palate: An Overview on Human Genetic and Environmental Risk Factors.非综合征性腭裂：人类遗传和环境风险因素概述
Front Cell Dev Biol. 2020 Oct 20;8:592271. doi: 10.3389/fcell.2020.592271. eCollection 2020.
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Environmental mechanisms of orofacial clefts.口腔面裂的环境机制。
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Influence of Parental Exposure to Risk Factors in the Occurrence of Oral Clefts.父母暴露于风险因素对腭裂发生的影响。
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Spatial Clusters of Children with Cleft Lip and Palate and Their Association with Polluted Zones in the Monterrey Metropolitan Area.《蒙特雷大都市区唇腭裂儿童的空间聚类及其与污染区的关联》
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