Deli Chariklia K, Fatouros Ioannis G, Poulios Athanasios, Liakou Christina A, Draganidis Dimitrios, Papanikolaou Konstantinos, Rosvoglou Anastasia, Gatsas Athanasios, Georgakouli Kalliopi, Tsimeas Panagiotis, Jamurtas Athanasios Z
Department of Physical Education and Sport Science, School of Physical Education, Sport Science, and Dietetics, University of Thessaly, 42100 Trikala, Greece.
Department of Dietetics and Nutrition, School of Physical Education, Sport Science, and Dietetics, University of Thessaly, 42100 Trikala, Greece.
Life (Basel). 2024 Aug 15;14(8):1016. doi: 10.3390/life14081016.
Type 2 diabetes (T2D) is the predominant metabolic epidemic posing a major threat to global health. Growing evidence indicates that gut microbiota (GM) may critically influence the progression from normal glucose tolerance, to pre-diabetes, to T2D. On the other hand, regular exercise contributes to the prevention and/or treatment of the disease, and evidence suggests that a possible way regular exercise favorably affects T2D is by altering GM composition toward health-promoting bacteria. However, research regarding this potential effect of exercise-induced changes of GM on T2D and the associated mechanisms through which these effects are accomplished is limited. This review presents current data regarding the association of GM composition and T2D and the possible critical GM differentiation in the progression from normal glucose, to pre-diabetes, to T2D. Additionally, potential mechanisms through which GM may affect T2D are presented. The effect of exercise on GM composition and function on T2D progression is also discussed.
2型糖尿病（T2D）是主要的代谢性流行病，对全球健康构成重大威胁。越来越多的证据表明，肠道微生物群（GM）可能对从正常糖耐量到糖尿病前期再到T2D的进展产生关键影响。另一方面，规律运动有助于预防和/或治疗该疾病，并且有证据表明规律运动对T2D产生有利影响的一种可能方式是使GM组成向促进健康的细菌转变。然而，关于运动引起的GM变化对T2D的这种潜在影响以及实现这些影响的相关机制的研究有限。本综述介绍了关于GM组成与T2D的关联以及从正常血糖到糖尿病前期再到T2D进展过程中可能的关键GM差异的当前数据。此外，还介绍了GM可能影响T2D的潜在机制。还讨论了运动对GM组成和功能在T2D进展中的影响。
