混合神经肌肉训练改善久坐不动的超重和肥胖女性的心脏代谢健康并改变氧化还原状态：一项随机对照试验
Hybrid Neuromuscular Training Improves Cardiometabolic Health and Alters Redox Status in Inactive Overweight and Obese Women: A Randomized Controlled Trial.
作者信息
Batrakoulis Alexios, Jamurtas Athanasios Z, Draganidis Dimitrios, Georgakouli Kalliopi, Tsimeas Panagiotis, Poulios Athanasios, Syrou Niki, Deli Chariklia K, Papanikolaou Konstantinos, Tournis Symeon, Fatouros Ioannis G
机构信息
Department of Physical Education and Sport Sciences, University of Thessaly, 42100 Trikala, Greece.
Department of Nutrition and Dietetics, University of Thessaly, 42100 Trikala, Greece.
出版信息
Antioxidants (Basel). 2021 Oct 12;10(10):1601. doi: 10.3390/antiox10101601.
This randomized controlled trial investigated the effects of a 5-month high-intensity hybrid-type neuromuscular training program with nontraditional implements on cardiometabolic health, redox status, and cardiovascular disease (CVD) risk in inactive overweight and obese women. Forty-nine inactive female participants with overweight and obesity (age: 36.4 ± 4.4 years; BMI: 29.1 ± 2.9 kg/m) were randomly assigned to either a control (C, = 21) or a training group (TR, = 28). TR followed a 20-week supervised, progressive, time-efficient (3 days/week; 6-15 min net exercise time) program implementing loaded fundamental movement patterns with prescribed work-to-rest time intervals (20-40 s, 1:2, 1:1, 2:1) in a circuit fashion (2-3 rounds). Cardiometabolic risk factors were measured at baseline and post-training as secondary outcomes of a larger randomized controlled trial. At post-intervention, TR demonstrated favorable changes in resting heart rate (-7%, = 0.043), high-density lipoprotein (+18.1%, = 0.029), atherogenic index (-17%, = 0.045), mean arterial pressure (-4.5%, = 0.03), waist circumference (-6.2%, = 0.005), waist-to-hip ratio (-4.6%; = 0.015), metabolic syndrome severity score (-222%, = 0.024), full 30-year CVD risk (-15.8%, = 0.002) and hard 30-year CVD risk (-17.6%, = 0.01), vascular age (-7.8%, = 0.002), protein carbonyls (-45.7%, = 0.001), catalase activity (+15.2%, = 0.023), and total antioxidant capacity (+11.4%, = 0.002) relative to C. Additionally, TR induced beneficial changes in fasting glucose (-3.4%, = 0.002), homeostatic model assessment for insulin resistance (-15.7%, < 0.001), diastolic blood pressure (-5.6%, < 0.001), reduced glutathione (+39.8%, < 0.001), 10-year CVD risk (-17.4%, = 0.011), and total bilirubin (-21.7%, < 0.001) compared to baseline. These results suggest that hybrid-type neuromuscular training may improve aspects of cardiometabolic health and antioxidant status in inactive overweight and obese women providing a time-efficient (~100 min/week) exercise approach in a real-world gym setting.
这项随机对照试验研究了一项为期5个月的高强度混合型神经肌肉训练计划（使用非传统器械）对缺乏运动的超重和肥胖女性的心脏代谢健康、氧化还原状态和心血管疾病（CVD）风险的影响。49名缺乏运动的超重和肥胖女性参与者（年龄：36.4±4.4岁；BMI：29.1±2.9kg/m²）被随机分配到对照组（C，n = 21）或训练组（TR，n = 28）。TR组遵循一项为期20周的有监督、渐进式、省时（每周3天；净运动时间6 - 15分钟）的计划，以循环方式（2 - 3轮）实施负荷基本运动模式，并规定了工作与休息时间间隔（20 - 40秒，1:2，1:1，2:1）。作为一项更大规模随机对照试验的次要结果，在基线和训练后测量了心脏代谢风险因素。干预后，与对照组相比，TR组在静息心率（-7%，P = 0.043）、高密度脂蛋白（+18.1%，P = 0.029）、致动脉粥样硬化指数（-17%，P = 0.045）、平均动脉压（-4.5%，P = 0.03）、腰围（-6.2%，P = 0.005）、腰臀比（-4.6%；P = 0.015）、代谢综合征严重程度评分（-222%，P = 0.024）、30年全因CVD风险（-15.8%，P = 0.002）和30年严重CVD风险（-17.6%，P = 0.01）、血管年龄（-7.�%，P = 0.002）、蛋白质羰基（-45.7%，P = 0.001）、过氧化氢酶活性（+15.2%，P = 0.023）和总抗氧化能力（+11.4%，P = 0.002）方面表现出有利变化。此外，与基线相比，TR组在空腹血糖（-3.4%，P = 0.002）、胰岛素抵抗稳态模型评估（-15.7%，P < 0.001）、舒张压（-5.6%，P < 0.001）、还原型谷胱甘肽（+39.8%，P < 0.001）、10年CVD风险（-17.4%，P = 0.011）和总胆红素（-21.7%，P < 0.001）方面也产生了有益变化。这些结果表明，混合型神经肌肉训练可能改善缺乏运动的超重和肥胖女性的心脏代谢健康和抗氧化状态，在现实世界的健身房环境中提供了一种省时（约每周100分钟）的运动方法。
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