Graduate Institute of Biomedical Science, China Medical University, Taichung, Taiwan, R.O.C.
Department of Neurosurgery, Neurological Institute, Taichung Veterans General Hospital, Taichung, Taiwan, R.O.C.
Anticancer Res. 2021 May;41(5):2451-2457. doi: 10.21873/anticanres.15020.
BACKGROUND/AIM: Triple negative breast cancer (TNBC) is characterized by increased recurrence and poor survival. Mounting evidence suggests that interleukin-10 (IL-10) plays a role in carcinogenesis, however, little is known about the contribution of IL-10 to TNBC. The study evaluated the contribution of IL-10 promoter A-1082G (rs1800896), T-819C (rs3021097), A-592C (rs1800872) genotypes to the risk of TNBC.
IL-10 genotypes were examined among 1,232 breast cancer patients and 1,232 controls and evaluated.
The percentages of AG and GG for IL-10 A-1082G genotypes were higher in the breast cancer patient group than in the control group. The GG genotype carriers were of higher risk for breast cancer [odds ratio (OR)=2.02, 95% confidence interval (CI)=1.28-3.21, p=0.0021]. Interestingly, G allele carriers were of higher risk of TNBC (OR=1.25, 95%CI=1.07-1.46, p=0.0050).
The G allele of IL-10 A-1082G genotype may serve as a predictor for TNBC risk. The finding should be validated in other populations.
背景/目的：三阴性乳腺癌（TNBC）的特点是复发率增加和生存率差。越来越多的证据表明白细胞介素 10（IL-10）在致癌作用中起作用，然而，IL-10 对 TNBC 的贡献知之甚少。本研究评估了白细胞介素 10 启动子 A-1082G（rs1800896）、T-819C（rs3021097）、A-592C（rs1800872）基因型对 TNBC 风险的贡献。
检查了 1232 例乳腺癌患者和 1232 例对照者的白细胞介素 10 基因型，并进行了评估。
IL-10 A-1082G 基因型的 AG 和 GG 百分比在乳腺癌患者组中高于对照组。GG 基因型携带者患乳腺癌的风险更高[比值比（OR）=2.02，95%置信区间（CI）=1.28-3.21，p=0.0021]。有趣的是，G 等位基因携带者患 TNBC 的风险更高（OR=1.25，95%CI=1.07-1.46，p=0.0050）。
IL-10 A-1082G 基因型的 G 等位基因可能是 TNBC 风险的预测因子。这一发现应在其他人群中得到验证。
