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级联羟基自由基生成和铁死亡诱导纳米纤维系统治疗口腔鳞状细胞癌。

Cascade Hydroxyl Radical-Generating and Ferroptosis-Inducing Nanofiber System for the Therapy of Oral Squamous Cell Carcinoma.

机构信息

Department of Pharmacy, College of Pharmacy, Kangwon National University, Chuncheon 24341, Republic of Korea.

Kangwon Institute of Inclusive Technology, Kangwon National University, Chuncheon 24341, Republic of Korea.

出版信息

Molecules. 2024 Aug 22;29(16):3964. doi: 10.3390/molecules29163964.

DOI:10.3390/molecules29163964
PMID:39203042
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11357578/
Abstract

Nanofiber (NF) membrane systems that can provide cascade catalytic reaction and ferroptosis induction were developed for oral cancer therapy. Glucose oxidase (GOx) and aminoferrocene (AF) were introduced into the NF system for glucose deprivation/HO generation and OH radical generation, respectively. GOx offers starvation therapy and AF (including iron) provides chemodynamic therapy/ferroptosis for combating oral cancer. GOx (water-soluble) and AF (poorly water-soluble) molecules were successfully entrapped in the NF membrane via an electrospinning process. GOx and AF were incorporated into the polyvinyl alcohol (PVA)-based NF, resulting in PVA/GOx/AF NF with fast disintegration and immediate drug-release properties. In oral squamous cell carcinoma (YD-9 cells), the PVA/GOx/AF NF group exhibited higher cytotoxicity, antiproliferation potential, cellular ROS level, apoptosis induction, lipid ROS level, and malondialdehyde level compared to the other NF groups. The electrospun PVA/GOx/AF NF can be directly applied to oral cancer without causing pain, offering starvation/chemodynamic therapy and ferroptosis induction.

摘要

用于口腔癌治疗的纳米纤维（NF）膜系统，可以提供级联催化反应和铁死亡诱导。葡萄糖氧化酶（GOx）和氨基二茂铁（AF）被引入 NF 系统，分别用于葡萄糖剥夺/HO 生成和 OH 自由基生成。GOx 提供饥饿疗法，AF（包括铁）提供化学动力学疗法/铁死亡来对抗口腔癌。GOx（水溶性）和 AF（水溶性差）分子通过静电纺丝工艺成功地包封在 NF 膜中。GOx 和 AF 被掺入基于聚乙烯醇（PVA）的 NF 中，导致具有快速崩解和立即药物释放特性的 PVA/GOx/AF NF。在口腔鳞状细胞癌（YD-9 细胞）中，与其他 NF 组相比，PVA/GOx/AF NF 组表现出更高的细胞毒性、抗增殖潜力、细胞 ROS 水平、细胞凋亡诱导、脂质 ROS 水平和丙二醛水平。电纺的 PVA/GOx/AF NF 可直接应用于口腔癌，而不会引起疼痛，提供饥饿/化学动力学疗法和铁死亡诱导。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0067/11357578/728ca174e115/molecules-29-03964-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0067/11357578/87690779e50b/molecules-29-03964-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0067/11357578/6078e2fe1545/molecules-29-03964-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0067/11357578/44c9ab796753/molecules-29-03964-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0067/11357578/24dee8755ed8/molecules-29-03964-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0067/11357578/c8c8f1d9ac6e/molecules-29-03964-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0067/11357578/e31f85840c3e/molecules-29-03964-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0067/11357578/728ca174e115/molecules-29-03964-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0067/11357578/87690779e50b/molecules-29-03964-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0067/11357578/6078e2fe1545/molecules-29-03964-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0067/11357578/44c9ab796753/molecules-29-03964-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0067/11357578/24dee8755ed8/molecules-29-03964-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0067/11357578/c8c8f1d9ac6e/molecules-29-03964-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0067/11357578/e31f85840c3e/molecules-29-03964-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0067/11357578/728ca174e115/molecules-29-03964-g007.jpg

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