Li Xu, Ding Wenyan, Li Zicheng, Yan Yi, Tong Yigang, Xu Jialiang, Li Mengzhe
School of Light Industry Science and Engineering, Beijing Technology and Business University, Beijing 102401, China.
College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China.
Microorganisms. 2024 Jul 31;12(8):1566. doi: 10.3390/microorganisms12081566.
Acne vulgaris is a prevalent chronic inflammatory skin disease, most common in adolescence and often persisting into adulthood, leading to severe physical and psychological impacts. The primary etiological factor is infection. The overuse of antibiotics for acne treatment over recent decades has led to the emergence of antibiotic-resistant strains. In this study, we isolated and characterized a novel bacteriophage, , from saliva samples. The average nucleotide identity analysis indicated that is a new species within the genus, enhancing our understanding of this underexplored group. demonstrates favorable stability, lacks potentially harmful genetic elements (virulence factors, antibiotic resistance genes, transposons, and integrases), and exhibits potent lytic and anti-biofilm activities against at low concentrations. These advantages highlight 's potential as a promising antibacterial agent that could possibly be complementary to antibiotics or other treatments for acne therapy.
寻常痤疮是一种常见的慢性炎症性皮肤病，在青少年中最为常见，且常常持续至成年期，会导致严重的生理和心理影响。主要病因是感染。近几十年来，抗生素在痤疮治疗中的过度使用导致了抗生素耐药菌株的出现。在本研究中，我们从唾液样本中分离并鉴定了一种新型噬菌体， 。平均核苷酸同一性分析表明， 是 属内的一个新物种，增进了我们对这个研究不足的类群的了解。 表现出良好的稳定性，缺乏潜在有害的遗传元件（毒力因子、抗生素抗性基因、转座子和整合酶），并在低浓度下对 表现出强大的裂解和抗生物膜活性。这些优势凸显了 作为一种有前景的抗菌剂的潜力，它可能成为抗生素或痤疮治疗其他疗法的补充。
