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人乳寡糖和益生菌对自闭症患者肠道微生物群和情绪的影响：一例报告

Impact of Human Milk Oligosaccharides and Probiotics on Gut Microbiome and Mood in Autism: A Case Report.

作者信息

Aldegheri Luana, Kharrat Feras, Conti Andrea, Monica Fabio, Busa Francesca, Campisciano Giuseppina, Zanotta Nunzia, Cason Carolina, Comar Manola

机构信息

Institute for Maternal and Child Health-IRCCS Burlo Garofolo, 65/1 Via dell'Istria, 34137 Trieste, Italy.

Department of Gastroenterology and Endoscopy, Trieste University Hospital, Strada di Fiume 447, 34149 Trieste, Italy.

出版信息

Microorganisms. 2024 Aug 9;12(8):1625. doi: 10.3390/microorganisms12081625.

DOI:10.3390/microorganisms12081625
PMID:39203467
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11356532/
Abstract

Recent evidence has highlighted the role of the gut-brain axis in the progression of autism spectrum disorder (ASD), with significant changes in the gut microbiome of individuals with this condition. This report investigates the effects of probiotics and human milk oligosaccharide (HMO) supplements on the gut microbiome, inflammatory cytokine profile, and clinical outcomes in an ASD adolescent with chronic gastrointestinal dysfunction and cognitive impairment. Following treatment, we observed a decrease in proinflammatory cytokines' concentration alongside relative abundance, a bacterium reported to be linked with gastrointestinal diseases. Also, we reported a notable increase in mood stability. The study aims to evaluate the use of gut microbiome-based therapy in selected ASD patients, highlighting its potential to improve related clinical symptoms.

摘要

最近的证据突显了肠-脑轴在自闭症谱系障碍（ASD）进展中的作用，患有这种疾病的个体肠道微生物群有显著变化。本报告调查了益生菌和人乳寡糖（HMO）补充剂对一名患有慢性胃肠功能障碍和认知障碍的ASD青少年的肠道微生物群、炎性细胞因子谱及临床结局的影响。治疗后，我们观察到促炎细胞因子浓度以及一种据报道与胃肠道疾病有关的细菌的相对丰度有所下降。此外，我们报告其情绪稳定性有显著提高。该研究旨在评估在选定的ASD患者中使用基于肠道微生物群的疗法，突显其改善相关临床症状的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a91d/11356532/eb9676c5d3e6/microorganisms-12-01625-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a91d/11356532/47e6a20ba65b/microorganisms-12-01625-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a91d/11356532/9e25651f7f48/microorganisms-12-01625-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a91d/11356532/18eb72f5f475/microorganisms-12-01625-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a91d/11356532/1adc4a02d708/microorganisms-12-01625-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a91d/11356532/eb9676c5d3e6/microorganisms-12-01625-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a91d/11356532/47e6a20ba65b/microorganisms-12-01625-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a91d/11356532/9e25651f7f48/microorganisms-12-01625-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a91d/11356532/18eb72f5f475/microorganisms-12-01625-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a91d/11356532/1adc4a02d708/microorganisms-12-01625-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a91d/11356532/eb9676c5d3e6/microorganisms-12-01625-g005.jpg

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Rice Byproduct Compounds: From Green Extraction to Antioxidant Properties.大米副产品化合物：从绿色提取到抗氧化特性
Antioxidants (Basel). 2023 Dec 23;13(1):35. doi: 10.3390/antiox13010035.
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Preparation and synbiotic interaction mechanism of microcapsules of Bifidobacterium animalis F1-7 and human milk oligosaccharides (HMO).
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Int J Biol Macromol. 2024 Feb;259(Pt 1):129152. doi: 10.1016/j.ijbiomac.2023.129152. Epub 2024 Jan 2.
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Bacteroides is increased in an autism cohort and induces autism-relevant behavioral changes in mice in a sex-dependent manner.脆弱拟杆菌在自闭症队列中增加，并以性别依赖的方式在小鼠中诱导与自闭症相关的行为变化。
NPJ Biofilms Microbiomes. 2023 Dec 18;9(1):103. doi: 10.1038/s41522-023-00469-2.
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subsp. Probio-M8 alleviates abnormal behavior and regulates gut microbiota in a mouse model suffering from autism.Probio-M8 亚种可缓解自闭症小鼠的异常行为并调节其肠道微生物群。
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