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人乳寡糖和益生菌对自闭症患者肠道微生物群和情绪的影响：一例报告

Impact of Human Milk Oligosaccharides and Probiotics on Gut Microbiome and Mood in Autism: A Case Report.

作者信息

Aldegheri Luana, Kharrat Feras, Conti Andrea, Monica Fabio, Busa Francesca, Campisciano Giuseppina, Zanotta Nunzia, Cason Carolina, Comar Manola

机构信息

Institute for Maternal and Child Health-IRCCS Burlo Garofolo, 65/1 Via dell'Istria, 34137 Trieste, Italy.

Department of Gastroenterology and Endoscopy, Trieste University Hospital, Strada di Fiume 447, 34149 Trieste, Italy.

出版信息

Microorganisms. 2024 Aug 9;12(8):1625. doi: 10.3390/microorganisms12081625.

DOI:10.3390/microorganisms12081625
PMID:39203467
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11356532/
Abstract

Recent evidence has highlighted the role of the gut-brain axis in the progression of autism spectrum disorder (ASD), with significant changes in the gut microbiome of individuals with this condition. This report investigates the effects of probiotics and human milk oligosaccharide (HMO) supplements on the gut microbiome, inflammatory cytokine profile, and clinical outcomes in an ASD adolescent with chronic gastrointestinal dysfunction and cognitive impairment. Following treatment, we observed a decrease in proinflammatory cytokines' concentration alongside relative abundance, a bacterium reported to be linked with gastrointestinal diseases. Also, we reported a notable increase in mood stability. The study aims to evaluate the use of gut microbiome-based therapy in selected ASD patients, highlighting its potential to improve related clinical symptoms.

摘要

最近的证据突显了肠-脑轴在自闭症谱系障碍（ASD）进展中的作用，患有这种疾病的个体肠道微生物群有显著变化。本报告调查了益生菌和人乳寡糖（HMO）补充剂对一名患有慢性胃肠功能障碍和认知障碍的ASD青少年的肠道微生物群、炎性细胞因子谱及临床结局的影响。治疗后，我们观察到促炎细胞因子浓度以及一种据报道与胃肠道疾病有关的细菌的相对丰度有所下降。此外，我们报告其情绪稳定性有显著提高。该研究旨在评估在选定的ASD患者中使用基于肠道微生物群的疗法，突显其改善相关临床症状的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a91d/11356532/eb9676c5d3e6/microorganisms-12-01625-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a91d/11356532/47e6a20ba65b/microorganisms-12-01625-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a91d/11356532/9e25651f7f48/microorganisms-12-01625-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a91d/11356532/18eb72f5f475/microorganisms-12-01625-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a91d/11356532/1adc4a02d708/microorganisms-12-01625-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a91d/11356532/eb9676c5d3e6/microorganisms-12-01625-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a91d/11356532/47e6a20ba65b/microorganisms-12-01625-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a91d/11356532/9e25651f7f48/microorganisms-12-01625-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a91d/11356532/18eb72f5f475/microorganisms-12-01625-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a91d/11356532/1adc4a02d708/microorganisms-12-01625-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a91d/11356532/eb9676c5d3e6/microorganisms-12-01625-g005.jpg

相似文献

[1]
Impact of Human Milk Oligosaccharides and Probiotics on Gut Microbiome and Mood in Autism: A Case Report.

Microorganisms. 2024-8-9

[2]
Probiotics and fructo-oligosaccharide intervention modulate the microbiota-gut brain axis to improve autism spectrum reducing also the hyper-serotonergic state and the dopamine metabolism disorder.

Pharmacol Res. 2020-7

[3]
New and Preliminary Evidence on Altered Oral and Gut Microbiota in Individuals with Autism Spectrum Disorder (ASD): Implications for ASD Diagnosis and Subtyping Based on Microbial Biomarkers.

Nutrients. 2019-9-6

[4]
Microbiota Transfer Therapy alters gut ecosystem and improves gastrointestinal and autism symptoms: an open-label study.

Microbiome. 2017-1-23

[5]
Precision synbiotics increase gut microbiome diversity and improve gastrointestinal symptoms in a pilot open-label study for autism spectrum disorder.

mSystems. 2024-5-16

[6]
The Human Gut Microbiome as a Potential Factor in Autism Spectrum Disorder.

Int J Mol Sci. 2022-1-25

[7]
Gut to brain interaction in Autism Spectrum Disorders: a randomized controlled trial on the role of probiotics on clinical, biochemical and neurophysiological parameters.

BMC Psychiatry. 2016-6-4

[8]
Harnessing the Gut Microbiome: To What Extent Can Pre-/Probiotics Alleviate Immune Activation in Autism Spectrum Disorder?

Nutrients. 2024-7-23

[9]
The Role of Microbiome, Dietary Supplements, and Probiotics in Autism Spectrum Disorder.

Int J Environ Res Public Health. 2020-4-12

[10]
Altered Autonomic Functions and Gut Microbiome in Individuals with Autism Spectrum Disorder (ASD): Implications for Assisting ASD Screening and Diagnosis.

J Autism Dev Disord. 2021-1

引用本文的文献

[1]
Interventions targeting the gut microbiota and their possible effect on gastrointestinal and neurobehavioral symptoms in autism spectrum disorder.

Gut Microbes. 2025-12

[2]
Human milk oligosaccharides: bridging the gap in intestinal microbiota between mothers and infants.

Front Cell Infect Microbiol. 2025-1-6

本文引用的文献

[1]
Microbiota-gut-brain axis and its therapeutic applications in neurodegenerative diseases.

Signal Transduct Target Ther. 2024-2-16

[2]
Rice Byproduct Compounds: From Green Extraction to Antioxidant Properties.

Antioxidants (Basel). 2023-12-23

[3]
Preparation and synbiotic interaction mechanism of microcapsules of Bifidobacterium animalis F1-7 and human milk oligosaccharides (HMO).

Int J Biol Macromol. 2024-2

[4]
Bacteroides is increased in an autism cohort and induces autism-relevant behavioral changes in mice in a sex-dependent manner.

NPJ Biofilms Microbiomes. 2023-12-18

[5]
subsp. Probio-M8 alleviates abnormal behavior and regulates gut microbiota in a mouse model suffering from autism.

mSystems. 2024-1-23

[6]
Gut-brain axis: gut dysbiosis and psychiatric disorders in Alzheimer's and Parkinson's disease.

Front Neurosci. 2023-11-13

[7]
Molecular strategies for the utilisation of human milk oligosaccharides by infant gut-associated bacteria.

FEMS Microbiol Rev. 2023-11-1

[8]
Novel Multi-Ingredient Supplement Facilitates Weight Loss and Improves Body Composition in Overweight and Obese Individuals: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.

Nutrients. 2023-8-23

[9]
Precision modulation of dysbiotic adult microbiomes with a human-milk-derived synbiotic reshapes gut microbial composition and metabolites.

Cell Host Microbe. 2023-9-13

[10]
Results of a phase Ib study of SB-121, an investigational probiotic formulation, a randomized controlled trial in participants with autism spectrum disorder.

Sci Rep. 2023-3-30

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