Perera Ruvindu, Alharbi Khawla, Hasan Amer, Asnayanti Andi, Do Anh, Shwani Abdulkarim, Murugesan Raj, Ramirez Shelby, Kidd Michael, Alrubaye Adnan A K
Cell and Molecular Biology Program, University of Arkansas, Fayetteville, AR 72701, USA.
Center of Excellence for Poultry Science, University of Arkansas, Fayetteville, AR 72701, USA.
Microorganisms. 2024 Aug 9;12(8):1630. doi: 10.3390/microorganisms12081630.
Bacterial chondronecrosis with osteomyelitis (BCO) lameness is a major welfare issue for broiler production worldwide affecting approximately 1.5% of broilers over 42 days old. Excessive body weight gain causes mechanical stress on long bones, leading to micro-fractures. This condition induces a bacterial infection of fractures, resulting in bone necrosis and eventual BCO lameness. Increasing gut integrity and supporting Calcium metabolism contribute to the optimal bone structure and subsequently reduce BCO lameness. Probiotics thus provide an excellent strategy for alleviating BCO due to the improvement of intestinal integrity and barrier function. Accordingly, the present study investigated the lameness reduction through the feed supplementation of a selected probiotic. Broiler chickens were assigned to three treatments, including a control litter group (FL), a PoultryStarBro probiotic fed group (BRO), and a control wire-flooring group (CW) designed to induce BCO lameness. The probiotic significantly decreased lameness by 46% compared to the control group ( < 0.05). The most predominant bacteria identified from the BCO lesions were and . Moreover, significant increments of tight junction gene expression in jejunum and ileum, plus numerical improvements of body weight gain (BW; +360 g) and feed conversion ratio (FCR; -12 pts) were observed in BRO-supplemented birds.
伴有骨髓炎的细菌性软骨坏死（BCO）跛行是全球肉鸡生产中的一个主要福利问题，影响约1.5%的42日龄以上肉鸡。体重过度增加会对长骨造成机械压力，导致微骨折。这种情况会引发骨折部位的细菌感染，导致骨坏死并最终引发BCO跛行。增强肠道完整性并支持钙代谢有助于形成最佳的骨骼结构，进而减少BCO跛行。因此，由于益生菌能改善肠道完整性和屏障功能，所以它为缓解BCO提供了一种极佳的策略。据此，本研究通过在饲料中添加一种选定的益生菌来研究减少跛行的效果。将肉鸡分为三种处理组，包括一个垫料对照组（FL）、一个饲喂PoultryStarBro益生菌的组（BRO）以及一个旨在诱发BCO跛行的金属网地板对照组（CW）。与对照组相比，益生菌使跛行显著降低了46%（P<0.05）。从BCO病变中鉴定出的最主要细菌是[此处原文缺失细菌名称]和[此处原文缺失细菌名称]。此外，在补充了BRO的鸡中，观察到空肠和回肠紧密连接基因表达显著增加，体重增加（BW；+360克）和饲料转化率（FCR；-12个百分点）在数值上也有所改善。
