Pharmacology Laboratory, Institute of Research for Food Safety and Health IRC-FSH, Department of Health Sciences, University Magna Graecia of Catanzaro, 88100 Catanzaro, Italy.
Laboratory of Pharmaceutical Biology, IRC-FSH Department of Health Sciences, University Magna Graecia of Catanzaro, 88100 Catanzaro, Italy.
Nutrients. 2024 Aug 11;16(16):2651. doi: 10.3390/nu16162651.
Peri-menopausal discomfort can have a detrimental effect on the physical health of women due to physiological and behavioral changes. Estrogen and progesterone-based hormone therapy can alleviate menopausal symptoms, but estrogen supplementation may have negative health effects. The effectiveness of hormone replacement therapy using natural compounds for peri-menopausal disorders is still uncertain. Evidence from in vivo experiments indicates that L. extract in ovariectomized rats leads to better sexual behavior. The effect seems to be linked to the phytoestrogenic properties of ferutinin, the primary bioactive compound in the extract. The purpose of this study was to assess the clinical impact of L. extract (titrated at 20% ferutinin, and given at doses of 100 mg/die for 90 days) on the quality of life of 64 menopausal women. The clinical trial was randomized, double-blind, and placebo controlled. Our data showed that L. extract reduced by 67 + 9% all symptoms associated to postmenopausal discomfort and enhanced significantly sexual behavior. In addition, the supplement led to a significant improvement of BMI and oxidative stress decrease in the women who received it, while also keeping platelet aggregation within normal levels. Overall, these results could point to the potential use of supplementation with L. extract to revert or mitigate menopause dysfunction.
围绝经期不适会对女性的身体健康产生不利影响，这是由于生理和行为的变化。雌激素和孕激素为基础的激素疗法可以缓解更年期症状，但雌激素补充可能有负面健康影响。用天然化合物治疗围绝经期疾病的激素替代疗法的有效性仍不确定。体内实验的证据表明，在去卵巢大鼠中， L.提取物可导致更好的性行为。这种效果似乎与提取物中主要生物活性化合物 ferutinin 的植物雌激素特性有关。本研究旨在评估 L.提取物（在 20% ferutinin 时进行滴定，并以 100 毫克/天的剂量给予 90 天）对 64 名绝经后妇女生活质量的临床影响。临床试验是随机、双盲和安慰剂对照的。我们的数据表明， L.提取物可使与绝经后不适相关的所有症状减少 67+9%，并显著增强性行为。此外，该补充剂可使接受治疗的女性的 BMI 和氧化应激显著改善，并使血小板聚集保持在正常水平。总的来说，这些结果可能表明，用 L.提取物补充可能有助于逆转或减轻更年期功能障碍。
