Department of Health and Human Performance, Concordia University Chicago, River Forest, IL 60305, USA.
Energy Balance & Body Composition Laboratory, Department of Kinesiology & Sport Management, Texas Tech University, Lubbock, TX 79409, USA.
Nutrients. 2024 Aug 20;16(16):2767. doi: 10.3390/nu16162767.
Caffeine's metabolism is determined by CYP1A2 genotypes: AC/CC (SLOW) and AA (FAST). This trial evaluated CYP1A2 genotypes' impact on exercise and cognitive effects in 36 resistance-trained females assessed under placebo (PL) and caffeine (6 mg/kg bw anhydrous caffeine-CAF) conditions, before ingestion and throughout the session. 23andMe (San Francisco, CA, USA) determined genotypes using saliva. Data were analyzed using two-way RMANOVA and paired-samples -tests ( < 0.05). A significant main effect for genotype existed for leg press repetitions to failure (RTF) for CAF ( = 0.038), with the FAST group performing more repetitions than the SLOW ( = 0.027). There was a significant condition x genotype interaction for the subjective outcome index score ( = 0.045), with significant differences for time ( < 0.01) and between genotype ( < 0.001). Follow-up analysis revealed a higher total score ( = 0.028) following CAF for the FAST group and a lower total score ( < 0.01) in the SLOW group. Dizziness was reported following CAF in the SLOW group ( = 0.014; Cohen's = 0.725). Aside from leg press RTF, subjective outcome index score, and dizziness, the genotype groups experienced similar responses to resistance exercise performance and subjective mood states following caffeine ingestion.
咖啡因的代谢由 CYP1A2 基因型决定：AC/CC（慢代谢型）和 AA（快代谢型）。本试验评估了 CYP1A2 基因型对 36 名接受安慰剂（PL）和咖啡因（6mg/kgbw 无水咖啡因-CAF）条件下的阻力训练女性的运动和认知影响的影响，在摄入前和整个过程中进行评估。23andMe（旧金山，加利福尼亚州，美国）使用唾液确定基因型。使用双向 RMANOVA 和配对样本 t 检验（<0.05）分析数据。CAF 对腿推重复次数至力竭（RTF）存在显著的基因型主效应（=0.038），快代谢型组比慢代谢型组完成更多的重复次数（=0.027）。主观结果指数评分存在显著的条件 x 基因型交互作用（=0.045），时间（<0.01）和基因型之间存在显著差异（<0.001）。后续分析显示，在服用 CAF 后，快代谢型组的总评分更高（=0.028），而慢代谢型组的总评分更低（<0.01）。在慢代谢型组中，服用 CAF 后报告了头晕（=0.014；Cohen's=0.725）。除了腿推 RTF、主观结果指数评分和头晕外，基因型组在摄入咖啡因后对阻力运动表现和主观情绪状态的反应相似。
