亚基因组黄病毒 RNA 作为减毒活疫苗开发的关键靶标。
Subgenomic flavivirus RNA as key target for live-attenuated vaccine development.
机构信息
Wageningen University and Research, Laboratory of Virology, Wageningen, the Netherlands.
出版信息
J Virol. 2024 Jul 23;98(7):e0010023. doi: 10.1128/jvi.00100-23. Epub 2024 May 29.
Abstract
Live-attenuated flavivirus vaccines confer long-term protection against disease, but the design of attenuated flaviviruses does not follow a general approach. The non-coding, subgenomic flavivirus RNA (sfRNA) is produced by all flaviviruses and is an essential factor in viral pathogenesis and transmission. We argue that modulating sfRNA expression is a promising, universal strategy to finetune flavivirus attenuation for developing effective flavivirus vaccines of the future.
摘要
减毒的黄病毒疫苗可提供长期的疾病保护，但减毒黄病毒的设计并没有遵循一般的方法。非编码的亚基因组黄病毒 RNA（sfRNA）由所有黄病毒产生，是病毒发病机制和传播的一个重要因素。我们认为，调节 sfRNA 的表达是一种有前途的通用策略，可以微调黄病毒的减毒程度，从而开发出未来有效的黄病毒疫苗。
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