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针对……的诊断、治疗及疫苗进展:全面综述

Advancement in Diagnosis, Treatment, and Vaccines against : A Comprehensive Review.

作者信息

Rufino-Moya Pablo José, Zafra Leva Rafael, Martínez-Moreno Álvaro, Buffoni Leandro, Valderas García Elora, Pérez Arévalo José, Molina-Hernández Verónica, Ruiz-Campillo María T, Herrera-Torres Guillem, Martínez-Moreno Francisco J

机构信息

Animal Health Department (Parasitology and Parasitic Diseases), Faculty of Veterinary Medicine, University of Córdoba, Sanidad Animal Building, Rabanales Campus, 14014 Córdoba, Spain.

UIC Zoonosis y Enfermedades Emergentes (ENZOEM), Faculty of Veterinary Medicine, University of Córdoba, Sanidad Animal Building, Rabanales Campus, 14014 Córdoba, Spain.

出版信息

Pathogens. 2024 Aug 7;13(8):669. doi: 10.3390/pathogens13080669.

DOI:10.3390/pathogens13080669
PMID:39204269
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11357060/
Abstract

In this review article, we aim to provide an overview of fasciolosis in ruminants. Diagnosis through new coprological methods (such as Flukefinder, FLOTAC, and Mini-FLOTAC) remains the most suitable approach for farms. Regarding treatment, there is a scarcity of available drugs, and resistance to them has prompted new approaches (including drug combinations, enhanced metabolism, or the use of natural compounds) to address this issue. Additionally, several researchers have developed vaccines to control the disease, but their efficacy varies, and none are currently sufficient for commercial use. Further studies are needed to better understand all aspects discussed in this manuscript, with the goal of improving diagnosis, treatment, and disease control. It is important to note that this manuscript does not delve into in-depth knowledge of the discussed aspects; rather, it provides an overview of the different methodologies related to these three aspects of parasitic disease.

摘要

在这篇综述文章中,我们旨在概述反刍动物的片形吸虫病。通过新的粪便学方法(如吸虫检测法、FLOTAC法和微型FLOTAC法)进行诊断仍然是养殖场最合适的方法。在治疗方面,可用药物稀缺,对药物的耐药性促使人们采用新的方法(包括药物组合、增强新陈代谢或使用天然化合物)来解决这一问题。此外,一些研究人员已经开发出控制该病的疫苗,但其疗效各不相同,目前还没有一种疫苗足以用于商业用途。需要进一步开展研究,以更好地理解本手稿中讨论的各个方面,目标是改善诊断、治疗和疾病控制。需要注意的是,本手稿并未深入探讨所讨论方面的详细知识;相反,它概述了与寄生虫病这三个方面相关的不同方法。

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本文引用的文献

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Evaluation of LAMP for Fasciola hepatica detection from faecal samples of experimentally and naturally infected cattle.用于从实验感染和自然感染牛的粪便样本中检测肝片吸虫的环介导等温扩增技术评估
Vet Parasitol. 2024 Apr;327:110132. doi: 10.1016/j.vetpar.2024.110132. Epub 2024 Jan 19.
2
Fosfatriclaben, a prodrug of triclabendazole: Preparation, stability, and fasciolicidal activity of three new intramuscular formulations.磷酸三氯苯达唑,三氯苯达唑的前体药物:三种新型肌肉注射制剂的制备、稳定性及杀片形吸虫活性
Vet Parasitol. 2024 Apr;327:110113. doi: 10.1016/j.vetpar.2024.110113. Epub 2024 Jan 12.
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Antibody detection against Kunitz-type protein in experimentally infected sheep using enzyme-linked immunosorbent assay (ELISA).使用酶联免疫吸附测定(ELISA)检测实验感染绵羊中针对库尼茨型蛋白的抗体。
Int J Vet Sci Med. 2023 Nov 14;11(1):126-137. doi: 10.1080/23144599.2023.2273678. eCollection 2023.
4
Identification and differentiation of Fasciola hepatica and F. gigantica using multiplex PCR technique.应用多重 PCR 技术鉴定和区分肝片形吸虫和巨片形吸虫。
Ann Parasitol. 2023;69(2):67-74. doi: 10.17420/ap6902.511.
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The use of cathepsin L1 (FhCL1) serological ELISA in sentinel screening for liver fluke on sheep farms.在绵羊养殖场使用组织蛋白酶 L1(FhCL1)血清 ELISA 进行肝片吸虫哨点筛查。
Vet Parasitol Reg Stud Reports. 2023 Oct;45:100924. doi: 10.1016/j.vprsr.2023.100924. Epub 2023 Aug 25.
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Development of a novel method for diagnosis of fasciolosis based on cathepsin L7 in ruminants.基于反刍动物组织蛋白酶L7的新型肝片吸虫病诊断方法的开发。
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