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埃及消除丙型肝炎:成功故事

Hepatitis C Elimination in Egypt: Story of Success.

作者信息

Gomaa Asmaa, Gomaa Mohamed, Allam Naglaa, Waked Imam

机构信息

Hepatology and Gastroenterology Department, National Liver Institute, Menofia University, Shebin El-Kom 32511, Egypt.

Faculty of Medicine and Health Sciences, University of Sherbrooke, Sherbrooke, QC J1H 5N4, Canada.

出版信息

Pathogens. 2024 Aug 12;13(8):681. doi: 10.3390/pathogens13080681.

DOI:10.3390/pathogens13080681
PMID:39204281
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11357586/
Abstract

Egypt has long been overwhelmed by the hepatitis C virus (HCV) infection, and it used to be the country with the world's highest prevalence rates. The disease had been a significant public health problem, affecting millions of Egyptians and posing severe economic and social challenges. By the early 2000s, it was estimated that around 10% of the Egyptian population was infected with HCV. However, in recent years, with the availability of direct-acting antiviral therapies, the country has made enormous steps in combating this public health threat. The combination of innovative health strategies and political will enabled Egypt to establish a successful model of care for HCV management and to be the first country to eliminate hepatitis C, setting a model for the rest of the world. In 2023, Egypt became the first country to fulfill the World Health Organization's set programmatic criteria of reduction of hepatitis C incidence and mortalities to levels close to elimination of disease or achieve the "gold tier" status on the path to disease elimination.

摘要

长期以来,埃及一直深受丙型肝炎病毒(HCV)感染的困扰,它曾是全球患病率最高的国家。这种疾病曾是一个重大的公共卫生问题,影响着数百万埃及人,并带来了严峻的经济和社会挑战。到21世纪初,据估计约10%的埃及人口感染了丙型肝炎病毒。然而,近年来,随着直接抗病毒疗法的出现,该国在应对这一公共卫生威胁方面取得了巨大进展。创新的卫生策略与政治意愿相结合,使埃及建立了一个成功的丙型肝炎管理护理模式,并成为首个消除丙型肝炎的国家,为世界其他国家树立了榜样。2023年,埃及成为首个达到世界卫生组织设定的将丙型肝炎发病率和死亡率降低到接近消除疾病水平的规划标准的国家,或在疾病消除之路上达到“黄金级别”的国家。

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本文引用的文献

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Impacts of the Egyptian national screening and treatment programme for viral hepatitis C: A cost-effectiveness model.埃及丙型肝炎病毒国家筛查和治疗计划的影响:成本效益模型。
Liver Int. 2023 Jul;43(7):1417-1426. doi: 10.1111/liv.15584. Epub 2023 Apr 18.
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Case study of hepatitis C virus control in Egypt: impact of access program.埃及丙型肝炎病毒控制案例研究:获得方案的影响。
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Global change in hepatitis C virus prevalence and cascade of care between 2015 and 2020: a modelling study.全球丙型肝炎病毒流行率的变化和 2015 年至 2020 年期间的治疗流程:建模研究。
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Decreased Incidence of Hepatocellular Carcinoma after Directly Acting Antiviral Therapy in Patients with Hepatitis C-Related Advanced Fibrosis and Cirrhosis.丙型肝炎相关晚期纤维化和肝硬化患者接受直接抗病毒治疗后肝细胞癌发病率降低
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