Park Hye-Shin, Kim Yu-Jin, Chang Soo-Jin, Lee Hae-Hyoung, Han Mi-Ran, Lee Joon-Haeng, Kim Jong-Soo, Kim Jong-Bin, Shin Ji-Sun, Lee Jung-Hwan
Department of Pediatric Dentistry, College of Dentistry, Dankook University, 119 Dandae-ro, Cheonan 31116, Republic of Korea.
Department of Biomaterials Science, College of Dentistry, Dankook University, 119 Dandae-ro, Cheonan 31116, Republic of Korea.
Pharmaceutics. 2024 Aug 2;16(8):1031. doi: 10.3390/pharmaceutics16081031.
Premature loss of root canal-treated primary teeth has long been a concern in dentistry. To address this, researchers developed a sodium iodide-based root canal-filling material as an alternative to traditional iodoform-based materials. The goal of this study was to improve the physicochemical properties of the sodium iodide-based material to meet clinical use standards. To resolve high solubility issues in the initial formulation, researchers adjusted component ratios and added new ingredients, resulting in a new paste called L5. This study compared L5 with L0 (identical composition minus lanolin) and Vitapex as controls, conducting physicochemical and antibacterial tests. Results showed that L5 met all ISO 6876 standards, demonstrated easier injection and irrigation properties than Vitapex, and exhibited comparable antibacterial efficacy to Vitapex, which is currently used clinically. The researchers conclude that if biological stability is further verified, L5 could potentially be presented as a new option for root canal-filling materials in primary teeth.
长期以来，根管治疗后的乳牙过早脱落一直是牙科领域关注的问题。为了解决这一问题，研究人员开发了一种基于碘化钠的根管充填材料，作为传统碘仿基材料的替代品。本研究的目的是改善碘化钠基材料的物理化学性质，以满足临床使用标准。为了解决初始配方中的高溶解性问题，研究人员调整了成分比例并添加了新成分，从而得到了一种名为L5的新型糊剂。本研究将L5与作为对照的L0（成分相同但不含羊毛脂）和Vitapex进行了比较，进行了物理化学和抗菌测试。结果表明，L5符合所有ISO 6876标准，比Vitapex具有更易于注射和冲洗的特性，并且表现出与目前临床使用的Vitapex相当的抗菌效果。研究人员得出结论，如果生物稳定性得到进一步验证，L5可能会成为乳牙根管充填材料的一种新选择。
