实体瘤中的小核仁 RNA：对这些潜在生物标志物的文献综述。
Small Nucleolar RNAs in Solid Tumors: A Brief Review of the Literature on These Potential Biomarkers.
机构信息
State University of Maranhão, Zé Doca, MA, Brazil.
Oncology Research Center, Federal University of Pará, Belém, Pará, Brazil.
出版信息
Asian Pac J Cancer Prev. 2024 Aug 1;25(8):2585-2591. doi: 10.31557/APJCP.2024.25.8.2585.
OBJECTIVE
The objective of this study was to conduct an integrative review, addressing the key findings, biological functions, and clinical significance of these biomolecules in solid tumors.
METHODS
This document analyzes the main data on the involvement of snoRNAs in solid tumors. For this, Pubmed and Science direct were used, with keywords. Additionally, a search for the host gene was conducted using the snoDB tool, and its chromosomal location was identified using the Hugo Gene Nomenclature Committee (HGNC).
RESULTS
According to research conducted in the literature, the majority of snoRNAs were found to be overexpressed and described as regulators of processes such as invasion, cellular proliferation, apoptosis, and migration. They are associated with clinical prognostic factors such as metastasis and worse survival.
CONCLUSION
Therefore, it is essential to expand the investigation of snoRNAs in oncology across different types of tumors. The utilization of these biomolecules may pave the way for innovative clinical applications, such as their use in the early detection of neoplasms in non-invasive samples and as therapeutic targets. Broadening research on snoRNAs across various tumor types is crucial.
目的
本研究旨在进行综合回顾，探讨这些生物分子在实体瘤中的主要发现、生物学功能和临床意义。
方法
本文件分析了 snoRNAs 参与实体瘤的主要数据。为此，使用了 Pubmed 和 Science direct，并使用了关键词。此外，使用 snoDB 工具进行了宿主基因的搜索，并使用人类基因命名委员会 (HGNC) 确定了其染色体位置。
结果
根据文献中的研究，大多数 snoRNAs 被发现过度表达，并被描述为调节侵袭、细胞增殖、凋亡和迁移等过程的调节剂。它们与转移和生存预后不良等临床预后因素相关。
结论
因此，有必要在不同类型的肿瘤中扩大 snoRNAs 在肿瘤学中的研究。这些生物分子的利用可能为创新的临床应用铺平道路，例如在非侵入性样本中早期检测肿瘤以及作为治疗靶点的应用。扩大对各种肿瘤类型 snoRNAs 的研究至关重要。
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