Department of Chemistry, College of Education, University of AL-Qadisiyah, Iraq.
Asian Pac J Cancer Prev. 2024 Aug 1;25(8):2919-2928. doi: 10.31557/APJCP.2024.25.8.2919.
The study aimed to investigate the effect of the aqueous extract of the chamomile plant on oxidative stress induced by procyclidine in rats. 30 rats were randomly divided into five groups, with 6 rats in each group. The first group was given distilled water only, while the second group was administered procyclidine (1 mg/kg body weight) in three doses daily for a period of 60 days. The third group was given procyclidine in the same doses as the second group for 30 days. Afterward, they were administered an aqueous extract of chamomile (300 mg/kg) for another 30 days. The fourth group was administered the aqueous extract (300 mg/kg) for 30 days. Subsequently, they were given procyclidine in the same doses as the second group for another 30 days. On the other hand, the fifth group was administered the aqueous extract of chamomile (300 mg/kg) for a period of 60 days to investigate the potential effects of the extract. Afterward, blood samples were drawn to measure various biological parameters, including Total Oxidant Status (TOS), Malondialdehyde (MDA), Aspartate Aminotransferase (AST), Alanine Transaminase (ALT), and Acetylcholinesterase (AChE) activity. Finally, an anatomical study was conducted on the kidneys, brain, and liver to enhance the research. The results displayed a significant increase in the levels of TOS, MDA, AST, ALT enzymes, and Ach-E activity in the second group compared to the first group. Groups 3 and 4 significantly decreased compared to the second group based on the same standards. In regard to Group 5, there are no significant moral differences between it and Group 1. Finally, this study demonstrated the importance of using chamomile extract as an antioxidant and its potential in cancer prevention against the oxidative stress induced by excessive doses of procyclidine. (p ≤ 0.005).
本研究旨在探讨甘菊植物水提物对普罗氯嗪诱导的大鼠氧化应激的影响。将 30 只大鼠随机分为 5 组，每组 6 只。第 1 组仅给予蒸馏水，第 2 组连续 60 天每日给予普罗氯嗪（1mg/kg 体重）3 次。第 3 组给予与第 2 组相同剂量的普罗氯嗪 30 天，然后给予甘菊水提物（300mg/kg）30 天。第 4 组给予甘菊水提物（300mg/kg）30 天，然后给予与第 2 组相同剂量的普罗氯嗪 30 天。另一方面，第 5 组给予甘菊水提物（300mg/kg）60 天，以研究提取物的潜在影响。之后，采集血样以测量各种生物参数，包括总氧化状态（TOS）、丙二醛（MDA）、天门冬氨酸氨基转移酶（AST）、丙氨酸氨基转移酶（ALT）和乙酰胆碱酯酶（AChE）活性。最后，对肾脏、大脑和肝脏进行解剖研究，以增强研究。结果显示，与第 1 组相比，第 2 组 TOS、MDA、AST、ALT 酶和 Ach-E 活性水平显著升高。与第 2 组相比，第 3 组和第 4 组显著降低。至于第 5 组，与第 1 组相比，它与第 1 组之间没有显著的道德差异。最后，这项研究表明，使用甘菊提取物作为抗氧化剂的重要性及其在预防过量普罗氯嗪诱导的氧化应激相关癌症方面的潜力。（p≤0.005）。
