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甲状腺功能减退对感官影响的研究:一项全面的叙述性综述。

A Study on the Effects of Hypothyroidism on the Senses: A Comprehensive Narrative Review.

作者信息

LeVasseur Eric, Fogel Maiah, Khanna Deepesh

机构信息

Foundational Sciences, Nova Southeastern University Dr. Kiran C. Patel College of Osteopathic Medicine, Clearwater, USA.

Foundational Sciences, Nova Southeastern University Dr. Kiran C. Patel College of Osteopathic Medicine, Fort Lauderdale, USA.

出版信息

Cureus. 2024 Jul 29;16(7):e65684. doi: 10.7759/cureus.65684. eCollection 2024 Jul.

DOI:10.7759/cureus.65684
PMID:39205767
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11357729/
Abstract

Hypothyroidism has been found to have long-term effects on each of the senses, but with proper treatment, many of them can be significantly minimized. This paper analyzes the research on the impact of hypothyroidism on the senses of smell, taste, hearing, vision, and thermoregulation. Data were collected from the National Library of Medicine, PubMed, and Google Scholar databases using the keywords "hypothyroidism," "taste," "smell," "vision," "hearing," and "thermoregulation." Approximately 413 articles were found when searching with these parameters, and 30 were used in this paper. Studies were excluded if they were outside this paper's scope or older than 2012. Studies were included if they specifically focused on hypothyroidism and one of the five listed senses. Patients with hypothyroidism had a significantly increased risk of sensorineural hearing loss, decreased perception of the blue-yellow color axis, decreased sense of olfaction and number of olfactory bulbs, and decreased thermogenesis. Hypothyroidism was also found to show increased length of COVID-19-induced anosmia and decreased bitter taste perception. It can be concluded that hypothyroidism has many effects on the senses, particularly an increased risk of sensorineural hearing loss. More studies need to be done on these effects.

摘要

甲状腺功能减退已被发现会对各种感官产生长期影响,但通过适当治疗,其中许多影响可显著减轻。本文分析了关于甲状腺功能减退对嗅觉、味觉、听觉、视觉和体温调节影响的研究。使用关键词“甲状腺功能减退”“味觉”“嗅觉”“视觉”“听觉”和“体温调节”从美国国立医学图书馆、PubMed和谷歌学术数据库收集数据。按这些参数搜索时大约找到413篇文章,本文使用了其中30篇。如果研究超出本文范围或早于2012年则被排除。如果研究专门关注甲状腺功能减退和所列五种感官之一,则被纳入。甲状腺功能减退患者感音神经性听力损失风险显著增加,对蓝黄色轴的感知下降,嗅觉和嗅球数量减少,产热减少。还发现甲状腺功能减退会使新冠病毒感染所致嗅觉丧失的持续时间延长,苦味感知下降。可以得出结论,甲状腺功能减退对感官有许多影响,尤其是感音神经性听力损失风险增加。需要对这些影响进行更多研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26d3/11357729/3d29245e14bd/cureus-0016-00000065684-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26d3/11357729/3d29245e14bd/cureus-0016-00000065684-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26d3/11357729/3d29245e14bd/cureus-0016-00000065684-i01.jpg

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本文引用的文献

1
Graves' Ophthalmopathy in the Setting of Primary Hypothyroidism.原发性甲状腺功能减退症背景下的格雷夫斯眼病
Cureus. 2022 May 12;14(5):e24954. doi: 10.7759/cureus.24954. eCollection 2022 May.
2
Evaluation of peripheral olfactory pathways in chronic autoimmune thyroiditis.慢性自身免疫性甲状腺炎外周嗅觉通路的评估。
Eur Arch Otorhinolaryngol. 2022 Sep;279(9):4525-4532. doi: 10.1007/s00405-022-07373-z. Epub 2022 Apr 18.
3
Leptin counteracts hypothermia in hypothyroidism through its pyrexic effects and by stabilizing serum thyroid hormone levels.
瘦素通过其发热作用和稳定血清甲状腺激素水平来对抗甲状腺功能减退症中的低体温。
Mol Metab. 2021 Dec;54:101348. doi: 10.1016/j.molmet.2021.101348. Epub 2021 Oct 2.
4
Dysfunction of the Auditory System in Children With Hypothyroidism: A Systematic Review and Meta-Analysis.甲状腺功能减退症患儿听觉系统功能障碍:一项系统评价和荟萃分析。
Ear Hear. 2022 Jan/Feb;43(1):23-31. doi: 10.1097/AUD.0000000000001082.
5
High Prevalence of Hearing Impairment in Primary Congenital Hypothyroidism.原发性先天性甲状腺功能减退症中听力障碍的高患病率。
Eur Thyroid J. 2021 Jun;10(3):215-221. doi: 10.1159/000509775. Epub 2020 Sep 3.
6
Hypothyroidism is associated with prolonged COVID-19-induced anosmia: a case-control study.甲状腺功能减退与新冠病毒感染后长期嗅觉丧失有关:一项病例对照研究。
J Neurol Neurosurg Psychiatry. 2021 Apr 20. doi: 10.1136/jnnp-2021-326587.
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Color discrimination assessment in patients with hypothyroidism using the Farnsworth-Munsell 100 hue test.使用 Farnsworth-Munsell 100 色调测试评估甲状腺功能减退症患者的颜色辨别能力。
J Opt Soc Am A Opt Image Sci Vis. 2020 Apr 1;37(4):A18-A25. doi: 10.1364/JOSAA.382390.
8
Taste disorder's management: a systematic review.味觉障碍的管理:系统评价。
Clin Oral Investig. 2020 Jun;24(6):1889-1908. doi: 10.1007/s00784-020-03299-0. Epub 2020 May 8.
9
Brown Adipose Tissue Response to Cold Stimulation Is Reduced in Girls With Autoimmune Hypothyroidism.自身免疫性甲状腺功能减退症女孩的棕色脂肪组织对冷刺激的反应减弱。
J Endocr Soc. 2019 Oct 11;3(12):2411-2426. doi: 10.1210/js.2019-00342. eCollection 2019 Dec 1.
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Adv Ther. 2019 Sep;36(Suppl 2):47-58. doi: 10.1007/s12325-019-01080-8. Epub 2019 Sep 4.