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复合移植物的挑战:利用荧光光能改善移植效果。

The challenge of composite graft: the use of fluorescent light energy to improve engraftment.

作者信息

Amabile Antonio, L'Erario Stefano, Scarpa Carlotta, Vindigni Vincenzo, Bassetto Franco, Marena Francesco

机构信息

Department of Neurosciences, University Hospital of Padua, Padova, Italy.

出版信息

Case Reports Plast Surg Hand Surg. 2024 Aug 27;11(1):2396946. doi: 10.1080/23320885.2024.2396946. eCollection 2024.

Abstract

Composite graft is a useful tool for the reconstruction of specific facial aesthetic subunits with a single surgical stage. This technique, when successful, gives optimal results in the reconstruction of small defects of nose, ear, eyelid and lips. The aim of this work is to optimize the attachment of composite grafts in the reconstruction of small complex facial defects by combining it with Fluorescent Light Energy (FLE) during the healing process of the graft. The beneficial effects of photobiomodulation (PBM) on wound healing might be attributed to anti-inflammatory signaling, cell proliferation, protein synthesis, and decreased bacterial infection. We previously experienced rewarding achievements using Photonic energy in the treatment of burns, non-healing wounds and pathological scars. Therefore, we chose to exploit the potential of bioluminescent energy to maximize aesthetical and functional results, enhancing the formation of new vascular connections and modulating both inflammatory and scarring processes. From the 2nd postoperative day, the patients were locally treated with 5 FLE sessions every (48/72 h) 2 or 3 days. We evaluated results in terms of time for engraftment, quality of the scarring, infective complications and morbidity of the donor site. Graft survival is subject to many factors, both local and systemic. To overcome these issues, various methods have been studied and described. We here report the successful reconstruction of full-thickness defects of the free margin of the nasal alar rim and the central portion of the inferior lip with a composite graft. These results were highly encouraging if compared with the literature. By analyzing our small cohort, we demonstrated how new technologies may push this traditional reconstructive procedure beyond their old boundaries: overcoming an increased size demand or a potential infective wound environment.

摘要

复合移植是在单一手术阶段重建特定面部美学亚单位的有用工具。该技术若成功,在鼻、耳、眼睑和唇部小缺损的重建中可产生最佳效果。本研究的目的是在复合移植愈合过程中,通过将其与荧光光能(FLE)相结合,优化复合移植在小而复杂面部缺损重建中的附着。光生物调节(PBM)对伤口愈合的有益作用可能归因于抗炎信号传导、细胞增殖、蛋白质合成以及细菌感染减少。我们之前在烧伤、不愈合伤口和病理性瘢痕的治疗中使用光子能量取得了丰硕成果。因此,我们选择利用生物发光能量的潜力,以最大化美学和功能效果,增强新血管连接的形成,并调节炎症和瘢痕形成过程。术后第2天起,患者每2或3天接受5次FLE局部治疗,每次间隔(48/72小时)。我们从移植成活时间、瘢痕质量、感染并发症和供区发病率方面评估结果。移植存活受多种局部和全身因素影响。为克服这些问题,人们研究并描述了各种方法。我们在此报告使用复合移植成功重建鼻翼缘游离缘全层缺损和下唇中央部分的情况。与文献相比,这些结果非常令人鼓舞。通过分析我们的小样本队列,我们展示了新技术如何将这种传统重建手术推至旧有界限之外:克服对更大尺寸的需求或潜在的感染性伤口环境。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ec9/11351365/9996b3c3c658/ICRP_A_2396946_F0001_C.jpg

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