Papadimitriou J M, Rigby P J
J Pathol. 1979 Oct;129(2):91-7. doi: 10.1002/path.1711290207.
Cinemicrographic investigations have shown multinucleate giant cells to be motile and contractile while immunofluorescent and biochemical studies have demonstrated the presence of actin-like proteins. These contractile proteins are concentrated in the centrospheric and perinuclear regions, while a more streaky distribution is present in the more peripheral parts of the polykaryon. This distribution corresponds with that of cytoplasmic filaments measuring 6-7 nm as seen by electron microscopy. The presence of similar proteins in macrophages, the precursor cells of multinucleate giant cells, indicates that these contractile proteins continue to be produced after macrophage fusion and that they are reorganised within the structural arrangements of the syncytium.
电影显微镜检查显示多核巨细胞具有运动性和收缩性，而免疫荧光和生化研究已证明存在肌动蛋白样蛋白。这些收缩蛋白集中在中心球和核周区域，而在多核体的更外围部分则呈现出更条纹状的分布。这种分布与电子显微镜观察到的6-7纳米细胞质细丝的分布相对应。多核巨细胞的前体细胞巨噬细胞中存在类似的蛋白质，这表明这些收缩蛋白在巨噬细胞融合后仍继续产生，并且它们在合体细胞的结构排列中重新组织。
