Akbalaeva Begimai, Raiimbek Uulu Nurlan, Gulamov Isabek, Abylov Kuttubek, Pershukov Igor
Department of Clinical Disciplines 1, Osh State University, Osh, Kyrgyz Republic.
Department of Pathology, Basis and Clinical Pharmacology, Osh State University, Osh, Kyrgyz Republic.
Acta Cardiol. 2024 Oct;79(8):886-896. doi: 10.1080/00015385.2024.2396762. Epub 2024 Aug 29.
In modern oncology, despite the efficacy of chemotherapy, there is a risk of cardiotoxicity resulting in heart failure. This necessitates early diagnosis to prevent complications and improve prognosis. The study is aimed at analysing the abilities of speckle-tracking echocardiography as a modern tool in detecting cardiotoxicity in the early stages. This non-invasive method allows evaluating myocardial strain and its contractility. During a thorough analysis and extensive review of the scientific literature, it was found that the speckle-tracking echocardiography technique demonstrates an exceptionally high sensitivity to detecting early signs of cardiotoxicity, significantly outpacing conventional echocardiography methods in this aspect. This advantage makes it an invaluable tool in the early detection of potentially dangerous changes in the myocardium, which is especially important for patients at risk of developing cardiotoxic reactions as a result of chemotherapy. Speckle-tracking echocardiography has a unique ability to identify even the slightest local abnormalities in the structure and function of the myocardium, significantly before any clinical symptoms become apparent, thereby allowing doctors to take preventive measures at the earliest stages. This outstanding diagnostic ability is supported by an extensive body of scientific research and publications that unequivocally confirm the effectiveness of speckle-tracking echocardiography as an advanced tool for the early diagnosis of cardiotoxic changes. Thus, the timely application of this technique can significantly reduce the risks to the cardiac health of patients and contribute to more effective treatment of oncological diseases. Speckle-tracking echocardiography serves as an important tool in the early detection of cardiotoxicity in patients undergoing chemotherapy, allowing clinicians to timely adapt treatment protocols and prevent the development of serious cardiovascular complications, thereby improving the prognosis and quality of life of cancer patients.
在现代肿瘤学中，尽管化疗有疗效，但存在心脏毒性风险，可导致心力衰竭。这就需要早期诊断以预防并发症并改善预后。本研究旨在分析斑点追踪超声心动图作为一种现代工具在早期检测心脏毒性方面的能力。这种非侵入性方法可用于评估心肌应变及其收缩性。在对科学文献进行全面分析和广泛综述时发现，斑点追踪超声心动图技术在检测心脏毒性早期迹象方面表现出极高的灵敏度，在这方面明显优于传统超声心动图方法。这一优势使其成为早期检测心肌潜在危险变化的宝贵工具，对于因化疗有发生心脏毒性反应风险的患者尤为重要。斑点追踪超声心动图具有独特能力，甚至能在任何临床症状出现之前很久就识别出心肌结构和功能中最细微的局部异常，从而使医生能够在最早阶段采取预防措施。大量科学研究和出版物支持了这种出色的诊断能力，明确证实了斑点追踪超声心动图作为早期诊断心脏毒性变化的先进工具的有效性。因此，及时应用该技术可显著降低患者心脏健康风险，并有助于更有效地治疗肿瘤疾病。斑点追踪超声心动图是化疗患者心脏毒性早期检测的重要工具，使临床医生能够及时调整治疗方案，预防严重心血管并发症的发生，从而改善癌症患者的预后和生活质量。
