Tîrziu Andreea-Talida, Susan Monica, Susan Razvan, Sonia Tanasescu, Harich Octavia Oana, Tudora Adelina, Varga Norberth-Istvan, Tiberiu-Liviu Dragomir, Avram Cecilia Roberta, Boru Casiana, Munteanu Mihnea, Horhat Florin George
Department of General Medicine, Doctoral School, "Victor Babes" University of Medicine and Pharmacy, 300041 Timisoara, Romania.
Department of Ophthalmology, "Victor Babes" University of Medicine and Pharmacy, 300041 Timisoara, Romania.
J Clin Med. 2024 Sep 21;13(18):5611. doi: 10.3390/jcm13185611.
The gut microbiome plays a crucial role in human health, and recent research has highlighted its potential impact on ocular health through the gut-eye axis. Dysbiosis, or an imbalance in the gut microbiota, has been implicated in various ocular diseases. A comprehensive literature search was conducted using relevant keywords in major electronic databases, prioritizing recent peer-reviewed articles published in English. The gut microbiota influences ocular health through immune modulation, maintenance of the blood-retinal barrier, and production of beneficial metabolites. Dysbiosis can disrupt these mechanisms, contributing to ocular inflammation, tissue damage, and disease progression in conditions such as uveitis, age-related macular degeneration, diabetic retinopathy, dry eye disease, and glaucoma. Therapeutic modulation of the gut microbiome through probiotics, prebiotics, synbiotics, and fecal microbiota transplantation shows promise in preclinical and preliminary human studies. The gut-eye axis represents a dynamic and complex interplay between the gut microbiome and ocular health. Targeting the gut microbiome through innovative therapeutic strategies holds potential for improving the prevention and management of various ocular diseases.
肠道微生物群在人类健康中起着至关重要的作用，最近的研究强调了其通过肠-眼轴对眼部健康的潜在影响。肠道微生物群失调，即肠道微生物群失衡，与多种眼部疾病有关。使用主要电子数据库中的相关关键词进行了全面的文献检索，优先选择最近以英文发表的同行评审文章。肠道微生物群通过免疫调节、维持血视网膜屏障和产生有益代谢物来影响眼部健康。微生物群失调会破坏这些机制，导致葡萄膜炎、年龄相关性黄斑变性、糖尿病视网膜病变、干眼症和青光眼等疾病中的眼部炎症、组织损伤和疾病进展。通过益生菌、益生元、合生元和粪便微生物群移植对肠道微生物群进行治疗性调节在临床前和初步人体研究中显示出前景。肠-眼轴代表了肠道微生物群与眼部健康之间动态而复杂的相互作用。通过创新治疗策略靶向肠道微生物群具有改善各种眼部疾病预防和管理的潜力。
