Laboratory of Epidemiology, Clinical Research and Community Health, Faculty of Medicine, Pharmacy and Dentistry, Sidi Mohamed Ben Abdellah University, Fez, Morocco
Epidemiology and Research in Health Sciences (ERESS) Research Laboratory, Faculty of Medicine, Pharmacy and Dentistry, Sidi Mohamed Ben Abdellah University, Fez, Morocco.
BMJ Open Respir Res. 2024 Aug 28;11(1):e002409. doi: 10.1136/bmjresp-2024-002409.
To investigate the association between biomass exposure and chronic obstructive pulmonary disease (COPD) in a representative sample of adults from the Moroccan population METHODS: A cross-sectional study was conducted in Fez as part of the Burden of Obstructive Lung Disease (BOLD) study, which included apparently healthy subjects aged 40 years and above. Biomass exposure was defined as self-report use of various biomass types for heating or cooking. The Wood Heating Exposure Index, and the Cooking Biomass Exposure Index were used to assess biomass exposure. Participants underwent post-bronchodilator spirometry and COPD was defined as having a forced expiratory volume in 1 s/forced vital capacity ratio <0.7. Descriptive, univariate and multivariable statistical analyses adjusting for potential confounders including age, sex, smoking, education level, Mokken scale (wealth index) and occupational dust exposure were performed for the general population and separately for men and women.
A total of 760 subjects were included, comprising 350 men and 410 women. In the multivariable analyses, we found a statistically significant association between a higher Wood Heating Exposure Index and COPD in men (adjusted OR=3.8; 95% CI: 1.4 to 10.4). While for women, a high Cooking Biomass Exposure Index was the main factor potentially linked to the increased risk of COPD (adjusted OR=7.2; 95% CI: 1.7 to 30.0).
This study suggests that biomass exposure is a significant risk factor for COPD development in both men and women, independently of the smoking status which is known as its main risk factor.
在摩洛哥人群的代表性成人样本中，研究生物量暴露与慢性阻塞性肺疾病（COPD）之间的关联。
横断面研究在非斯进行，作为阻塞性肺病负担（BOLD）研究的一部分，该研究纳入了年龄在 40 岁及以上的明显健康受试者。生物量暴露定义为自我报告使用各种生物量类型进行取暖或烹饪。使用 Wood Heating Exposure Index 和 Cooking Biomass Exposure Index 来评估生物量暴露。参与者接受支气管扩张剂后肺量测定，COPD 的定义为用力呼气量 1 秒/用力肺活量比<0.7。进行了描述性、单变量和多变量统计分析，调整了潜在混杂因素，包括年龄、性别、吸烟、教育水平、Mokken 量表（财富指数）和职业粉尘暴露，分析针对一般人群进行，并分别针对男性和女性进行。
共纳入 760 名受试者，其中包括 350 名男性和 410 名女性。在多变量分析中，我们发现男性较高的 Wood Heating Exposure Index 与 COPD 之间存在统计学显著关联（调整后的 OR=3.8；95%CI：1.4 至 10.4）。而对于女性，高 Cooking Biomass Exposure Index 是与 COPD 风险增加相关的主要因素（调整后的 OR=7.2；95%CI：1.7 至 30.0）。
这项研究表明，生物量暴露是男性和女性 COPD 发展的一个重要危险因素，独立于已知的主要危险因素吸烟。
