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[恒河猴阴性供血者红细胞中恒河猴阳性抗原活性的证明以及血液紫外线照射后ABO系统抗原表达的增加]

[Demonstration of the activity of a rhesus-positive antigen in the erythrocytes of rhesus-negative donors and an increase in the expression of ABO system antigens after ultraviolet irradiation of the blood].

作者信息

Samoĭlova K A, Klimova K N, Priezzheva L S, Artsishevskaia R A

出版信息

Biull Eksp Biol Med. 1985 Apr;99(4):460-2.

PMID:3921083
Abstract

UV irradiation (254 nm) in doses increasing erythrocyte (Er) hemolysis by 5 to 32% was found to stimulate the agglutination activity of ABO and Rhesus (Rh) system antigens. The stimulation effect was the higher the lower the antigen activity before irradiation. In the Rh-negative (Rh-)-Er, irradiation induced the Rh0(D)-like antigen specific activity suggesting that this antigen may be present in the Rh--Er membrane. Expression of Rh0(D)-antigen in Rh--Er, stimulation of its activity in Rh-positive cells, and activation of ABO system antigens may result from photo-chemical destruction of the outer membranous layer of the ER.

摘要

研究发现,紫外线(254纳米)照射剂量增加会使红细胞(Er)溶血率提高5%至32%,同时刺激ABO和恒河猴(Rh)系统抗原的凝集活性。照射前抗原活性越低,刺激效果越明显。在Rh阴性(Rh-)红细胞中,照射诱导出类似Rh0(D)的抗原特异性活性,这表明该抗原可能存在于Rh-红细胞膜中。Rh-红细胞中Rh0(D)抗原的表达、Rh阳性细胞中其活性的刺激以及ABO系统抗原的激活,可能是由于红细胞外膜层的光化学破坏所致。

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