Samoĭlova K A, Klimova K N, Priezzheva L S, Artsishevskaia R A
Biull Eksp Biol Med. 1985 Apr;99(4):460-2.
UV irradiation (254 nm) in doses increasing erythrocyte (Er) hemolysis by 5 to 32% was found to stimulate the agglutination activity of ABO and Rhesus (Rh) system antigens. The stimulation effect was the higher the lower the antigen activity before irradiation. In the Rh-negative (Rh-)-Er, irradiation induced the Rh0(D)-like antigen specific activity suggesting that this antigen may be present in the Rh--Er membrane. Expression of Rh0(D)-antigen in Rh--Er, stimulation of its activity in Rh-positive cells, and activation of ABO system antigens may result from photo-chemical destruction of the outer membranous layer of the ER.
研究发现,紫外线(254纳米)照射剂量增加会使红细胞(Er)溶血率提高5%至32%,同时刺激ABO和恒河猴(Rh)系统抗原的凝集活性。照射前抗原活性越低,刺激效果越明显。在Rh阴性(Rh-)红细胞中,照射诱导出类似Rh0(D)的抗原特异性活性,这表明该抗原可能存在于Rh-红细胞膜中。Rh-红细胞中Rh0(D)抗原的表达、Rh阳性细胞中其活性的刺激以及ABO系统抗原的激活,可能是由于红细胞外膜层的光化学破坏所致。