Sharma B, Mehta S, Nain C K, Mathur V S
Drug Nutr Interact. 1986;4(4):333-8.
The disposition of chloramphenicol was studied in young rhesus monkeys at three levels of nutrition: control, protein-energy deficiency, and following nutritional rehabilitation. During the malnutrition phase, the plasma elimination half-life was prolonged and the plasma clearance was reduced. Simultaneously there was a decrease in the activity of chloramphenicol-specific UDP-glucuronyl transferase. These changes were reversible following nutritional rehabilitation.
对照、蛋白质-能量缺乏以及营养康复后。在营养不良阶段，血浆消除半衰期延长，血浆清除率降低。同时，氯霉素特异性UDP-葡萄糖醛酸转移酶的活性下降。营养康复后，这些变化是可逆的。
