Nehru B, Mehta S, Nain C K, Mathur V S
Department of Biophysics, Panjab University, Chandigarh, India.
Int J Clin Pharmacol Ther Toxicol. 1988 Oct;26(10):509-12.
Disposition of sulphadiazine was assessed in young rhesus monkeys under three stages of nutritional manipulations i.e. control, protein calorie malnutrition (PCM) state and following nutritional rehabilitation. There was no alteration in the absorption kinetics except a delayed peak in the malnourished group. A decrease in volume of distribution of drug in the peripheral compartment was noted. The most significant changes observed was in the elimination kinetic parameter. The (Ke) elimination rate constant and the clearance rate showed a significant decrease which could be either because of decreased rate of acetylation or a decrease volume of distribution.
在幼年恒河猴处于三个营养调控阶段，即对照、蛋白质热量营养不良（PCM）状态以及营养康复后，对磺胺嘧啶的处置情况进行了评估。除了营养不良组的峰值延迟外，吸收动力学没有改变。注意到药物在外周室的分布容积减小。观察到的最显著变化在于消除动力学参数。消除速率常数（Ke）和清除率显著降低，这可能是由于乙酰化速率降低或分布容积减小所致。
