Department of Pediatrics, Copenhagen Prospective Studies on Asthma in Childhood, Slagelse Hospital, Slagelse, Denmark.
Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
BMJ Paediatr Open. 2024 Aug 30;8(1):e002634. doi: 10.1136/bmjpo-2024-002634.
Atopic diseases, obesity and neuropsychiatric disorders are lifestyle-related and environmental-related chronic inflammatory disorders, and the incidences have increased in the last years.
To outline the design of the 18-year follow-up of the Copenhagen Prospective Study on Asthma in Childhood (COPSAC) birth cohort, where risk factors of atopic diseases, obesity and neuropsychiatric disorders are identified through extensive characterisation of the environment, along with deep clinical phenotyping and biosampling for omics profiling.
COPSAC is a Danish prospective clinical birth cohort study of 411 children born to mothers with asthma who were enrolled at 1 month of age and closely followed at the COPSAC clinical research unit through childhood for the development of atopic diseases. At the 18-year follow-up visit, biomaterial (hair, blood, urine, faeces, throat, and skin swabs, nasal lining fluid and scraping, and hypopharyngeal aspirates) and extensive information on environmental exposures and risk behaviours were collected along with deep metabolic characterisation and multiorgan investigations including anthropometrics, heart, lungs, kidneys, intestines, bones, muscles and skin. Neuropsychiatric diagnoses were captured from medical records and registers accompanied by electronic questionnaires on behavioural traits and psychopathology.
A total of 370 (90%) of the 411 cohort participants completed the 18-year visit. Of these, 25.1% had asthma, 23.4% had a body mass index >25 kg/m and 16.8% had a psychiatric diagnosis in childhood. A total of 68.7% drank alcohol monthly, and when drinking, 22.2% drank >10 units. Of the participants, 31.4% were currently smoking, and of these, 24.1% smoked daily. A total of 23.8% had tried taking drugs, and 19.7% reported having done self-destructive behaviour. The mean screen time per day was 6.0 hours.
This huge dataset on health and habits, exposures, metabolism, multiorgan assessments and biosamples from COPSAC by age 18 provides a unique opportunity to explore risk factors and underlying mechanisms of atopic disease and other lifestyle-related, non-communicable diseases such as obesity and neuropsychiatric disorders, which are highly prevalent in the community and our cohort.
特应性疾病、肥胖和神经精神障碍是与生活方式和环境相关的慢性炎症性疾病，近年来发病率有所上升。
概述哥本哈根儿童哮喘前瞻性研究（COPSAC）出生队列的 18 年随访设计，该研究通过对环境进行广泛的特征描述，以及对临床表型进行深入的表型分析和生物样本采集进行组学分析，确定特应性疾病、肥胖和神经精神障碍的危险因素。
COPSAC 是一项丹麦前瞻性临床出生队列研究，共纳入 411 名母亲患有哮喘的儿童，他们在 1 个月大时入组，并在 COPSAC 临床研究单位通过儿童期密切随访，以观察特应性疾病的发生。在 18 年随访时，采集生物材料（头发、血液、尿液、粪便、咽喉和皮肤拭子、鼻黏膜液和刮片、咽抽吸物）以及广泛的环境暴露和风险行为信息，同时进行深入的代谢特征分析和多器官检查，包括人体测量学、心脏、肺、肾脏、肠道、骨骼、肌肉和皮肤。神经精神科诊断从病历和登记处获得，并附有行为特征和精神病理学的电子问卷。
在 411 名队列参与者中，共有 370 名（90%）完成了 18 年的随访。其中，25.1%患有哮喘，23.4%的人体质量指数（BMI）>25kg/m²，16.8%在儿童期有精神科诊断。68.7%的人每月饮酒，当饮酒时，22.2%的人饮酒量>10 单位。31.4%的参与者目前吸烟，其中 24.1%的人每天吸烟。23.8%的人尝试过吸毒，19.7%的人报告过自残行为。每天的平均屏幕时间为 6.0 小时。
COPSAC 在 18 岁时提供了一个独特的机会，可以通过对健康和习惯、暴露、代谢、多器官评估和生物样本的研究，来探索特应性疾病和其他与生活方式相关的非传染性疾病（如肥胖和神经精神障碍）的危险因素和潜在机制，这些疾病在社区和我们的队列中非常普遍。
