Yang Mengge, Wei Ying, Wang Ying, Liu Jia, Wang Guang
Department of Endocrinology, Beijing Chao-yang Hospital, Capital Medical University, Beijing, 100020, China.
Physical Examination Center, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020, China.
Hormones (Athens). 2025 Mar;24(1):231-239. doi: 10.1007/s42000-024-00596-1. Epub 2024 Aug 31.
The study aims to investigate the relationship between thyroid-stimulating hormone (TSH) and remnant cholesterol (RC) in euthyroid adults.
The adults who were recruited for the study had undergone physical examination at Beijing Chao-Yang Hospital. High RC levels were defined as the upper quartile of RC levels in males and females, respectively. The relationship between TSH and RC was assessed using the logistic and linear regression models.
A total of 29,708 adults (14,347 males and 15,361 females) were enrolled in this study. RC ≥ 0.77 mmol/L in males and RC ≥ 0.60 mmol/L in females were defined as high RC levels. With increasing serum TSH levels, the percentage of adults with high RC levels increased. The odds ratios (ORs (95% confidence intervals (CIs)) for high RC levels increased as TSH quartiles (Q) rose after full adjustments [males: Q2 1.11 (1.00-1.24), P < 0.05; Q3 1.03 (0.92-1.15), P > 0.05; Q4 1.25 (1.12-1.40), P < 0.001; and females: Q2 1.07 (0.96-1.20), P > 0.05; Q3 1.17 (1.05-1.31), P < 0.01, Q4 1.33 (1.20-1.48), P < 0.001, all P for trend < 0.001], using Q1 as the reference.
Higher TSH levels were independently associated with higher RC levels in euthyroid adults, this underscoring the significance of regulating TSH levels appropriately.
本研究旨在调查甲状腺功能正常的成年人中促甲状腺激素（TSH）与残余胆固醇（RC）之间的关系。
本研究招募的成年人在北京朝阳医院进行了体检。高RC水平分别定义为男性和女性RC水平的上四分位数。使用逻辑回归和线性回归模型评估TSH与RC之间的关系。
本研究共纳入29708名成年人（男性14347名，女性15361名）。男性RC≥0.77 mmol/L和女性RC≥0.60 mmol/L被定义为高RC水平。随着血清TSH水平升高，高RC水平成年人的百分比增加。在进行全面调整后，高RC水平的优势比（OR（95%置信区间（CI）））随着TSH四分位数（Q）升高而增加[男性：Q2为1.11（1.00 - 1.24），P < 0.05；Q3为1.03（0.92 - 1.15），P > 0.05；Q4为1.25（1.12 - 1.40），P < 0.001；女性：Q2为1.07（0.96 - 1.20），P > 0.05；Q3为1.17（1.05 - 1.31），P < 0.01，Q4为1.33（1.20 - 1.48），P < 0.001，所有趋势P < 0.001]，以Q1作为参考。
在甲状腺功能正常的成年人中，较高的TSH水平与较高的RC水平独立相关，这凸显了适当调节TSH水平的重要性。
