Henan International Joint Laboratory for Nuclear Protein Regulation, School of Basic Medical Sciences, School of Stomatology, Henan University, Kaifeng, Henan, 475004, China.
Department of Stomatology, The First Affiliated Hospital of Henan University, Kaifeng, Henan, 475001, China.
Exp Cell Res. 2024 Oct 1;442(2):114233. doi: 10.1016/j.yexcr.2024.114233. Epub 2024 Aug 30.
Gasotransmitters are endogenous gaseous signaling molecules that can freely pass through cell membranes and transmit signals between cells, playing multiple roles in cell signal transduction. Due to extensive and ongoing research in this field, we have successfully identified many gasotransmitters so far, among which nitric oxide, carbon monoxide, and hydrogen sulfide are best studied. Gasotransmitters are implicated in various diseases related to necroptosis, such as cardiovascular diseases, inflammation, ischemia-reperfusion, infectious diseases, and neurological diseases. However, the mechanisms of their effects on necroptosis are not fully understood. This review focuses on endogenous gasotransmitter synthesis and metabolism and discusses their roles in necroptosis, aiming to offer new insights for the therapeutic approaches to necroptosis-associated diseases.
气体信号分子是内源性的气态信号分子，可以自由穿过细胞膜，并在细胞间传递信号，在细胞信号转导中发挥多种作用。由于该领域的广泛和持续研究，到目前为止，我们已经成功地鉴定出许多气体信号分子，其中一氧化氮、一氧化碳和硫化氢的研究最为广泛。气体信号分子与多种与坏死性凋亡相关的疾病有关，如心血管疾病、炎症、缺血再灌注、传染病和神经退行性疾病。然而，它们对坏死性凋亡影响的机制尚不完全清楚。本综述重点介绍内源性气体信号分子的合成和代谢，并讨论它们在坏死性凋亡中的作用，旨在为坏死性凋亡相关疾病的治疗方法提供新的思路。
