Department of Clinical Epidemiology and Health Economics, School of Public Health, The University of Tokyo, Tokyo, Japan.
Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
Bone Joint J. 2024 Sep 1;106-B(9):986-993. doi: 10.1302/0301-620X.106B9.BJJ-2024-0089.R1.
The aim of this study was to compare the early postoperative mortality and morbidity in older patients with a fracture of the femoral neck, between those who underwent total hip arthroplasty (THA) and those who underwent hemiarthroplasty.
This nationwide, retrospective cohort study used data from the Japanese Diagnosis Procedure Combination database. We included older patients (aged ≥ 60 years) who underwent THA or hemiarthroplasty after a femoral neck fracture, between July 2010 and March 2022. A total of 165,123 patients were included. The THA group was younger (mean age 72.6 (SD 8.0) vs 80.7 years (SD 8.1)) and had fewer comorbidities than the hemiarthroplasty group. Patients with dementia or malignancy were excluded because they seldom undergo THA. The primary outcome measures were mortality and complications while in hospital, and secondary outcomes were readmission and reoperation within one and two years after discharge, and the costs of hospitalization. We conducted an instrumental variable analysis (IVA) using differential distance as a variable.
The IVA analysis showed that the THA group had a significantly higher rate of complications while in hospital (risk difference 6.3% (95% CI 2.0 to 10.6); p = 0.004) than the hemiarthroplasty group, but there was no significant difference in the rate of mortality while in hospital (risk difference 0.3% (95% CI -1.7 to 2.2); p = 0.774). There was no significant difference in the rate of readmission (within one year: risk difference 1.3% (95% CI -1.9 to 4.5); p = 0.443; within two years: risk difference 0.1% (95% CI -3.2 to 3.4); p = 0.950) and reoperation (within one year: risk difference 0.3% (95% CI -0.6 to 1.1); p = 0.557; within two years: risk difference 0.1% (95% CI -0.4 to 0.7); p = 0.632) after discharge. The costs of hospitalization were significantly higher in the THA group than in the hemiarthroplasty group (difference $2,634 (95% CI $2,496 to $2,772); p < 0.001).
Among older patients undergoing surgery for a femoral neck fracture, the risk of early complications was higher after THA than after hemiarthroplasty. Our findings should aid in clinical decision-making in these patients.
本研究旨在比较股骨颈骨折老年患者中接受全髋关节置换术(THA)和半髋关节置换术的患者的早期术后死亡率和发病率。
这是一项全国性的回顾性队列研究,使用了日本诊断程序组合数据库的数据。我们纳入了 2010 年 7 月至 2022 年 3 月期间因股骨颈骨折接受 THA 或半髋关节置换术的年龄≥60 岁的老年患者。共纳入 165123 名患者。THA 组患者年龄较小(平均年龄 72.6[标准差 8.0]岁 vs 80.7 岁[标准差 8.1]岁),合并症较少。由于很少有痴呆或恶性肿瘤患者接受 THA,因此排除了这些患者。主要结局指标为住院期间的死亡率和并发症,次要结局指标为出院后 1 年和 2 年内的再入院和再次手术,以及住院费用。我们使用差分距离作为变量进行了工具变量分析(IVA)。
IVA 分析显示,THA 组住院期间并发症发生率明显高于半髋关节置换术组(风险差异 6.3%(95%CI 2.0 至 10.6);p=0.004),但住院期间死亡率无显著差异(风险差异 0.3%(95%CI -1.7 至 2.2);p=0.774)。出院后 1 年内再入院率(风险差异 1.3%(95%CI -1.9 至 4.5);p=0.443)和 2 年内再入院率(风险差异 0.1%(95%CI -3.2 至 3.4);p=0.950)无显著差异,出院后 1 年内再次手术率(风险差异 0.3%(95%CI -0.6 至 1.1);p=0.557)和 2 年内再次手术率(风险差异 0.1%(95%CI -0.4 至 0.7);p=0.632)无显著差异。THA 组的住院费用明显高于半髋关节置换术组(差异 $2634(95%CI $2496 至 $2772);p<0.001)。
在接受股骨颈骨折手术的老年患者中,THA 术后早期并发症的风险高于半髋关节置换术。我们的研究结果应有助于这些患者的临床决策。