Biomaterials Technology Department, Faculty of Mechanical Engineering and Ship Technology, Gdańsk University of Technology, Gdańsk, Poland.
Scientific Club 'Materials in Medicine', Advanced Materials Centre, Gdańsk University of Technology, Gdańsk, Poland.
Sci Rep. 2024 Aug 31;14(1):20279. doi: 10.1038/s41598-024-70984-5.
Bone cement based on magnesium phosphate has extremely favorable properties for its application as a bioactive bone substitute. However, further improvement is still expected due to difficult injectability and high brittleness. This paper reported the preparation of novel biocomposite cement, classified as dual-setting, obtained through ceramic hydration reaction and polymer cross-linking. Cement was composed of magnesium potassium phosphate and sodium alginate cross-linked with calcium carbonate and gluconolactone. The properties of the obtained composite material and the influence of sodium alginate modification on cement reaction were investigated. Our results indicated that proposed cements have several advantages compared to ceramic cement, like shortened curing time, diverse microstructure, increased wettability and biodegradability and improved paste cohesion and injectability. The magnesium phosphate cement with 1.50% sodium alginate obtained using a powder-to-liquid ratio of 2.5 g/mL and cross-linking ratio 90/120 of GDL/CC showed the most favorable properties, with no adverse effect on mechanical strength and osteoblasts cytocompatibility. Overall, our research suggested that this novel cement might have promising medical application prospects, especially in minimally invasive procedures.
基于磷酸镁的骨水泥具有作为生物活性骨替代物的极好性能。然而，由于其可注射性差和脆性高，仍需要进一步改进。本文报道了一种新型的双固化生物复合水泥的制备，该水泥通过陶瓷水合反应和聚合物交联获得，分类为双固化。水泥由磷酸镁钾和交联碳酸钙与葡庚糖酸内酯的海藻酸钠组成。研究了所得复合材料的性能以及海藻酸钠改性对水泥反应的影响。与陶瓷水泥相比，我们的结果表明，所提出的水泥具有几个优点，如固化时间缩短、微观结构多样化、润湿性和生物降解性提高、糊剂凝聚力和可注射性改善。使用粉末与液体比为 2.5 g/mL 且交联比为 GDL/CC 90/120 的 1.50%海藻酸钠的磷酸镁水泥表现出最有利的性能，对机械强度和成骨细胞细胞相容性没有不利影响。总的来说，我们的研究表明，这种新型水泥可能具有有前途的医学应用前景，特别是在微创手术中。
