West China School of Basic Medical Sciences & Forensic Medicine, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China.
Center for Reproductive Medicine, Department of Gynecology and Obstetrics, West China Second University Hospital, Sichuan University, Chengdu, 610041, China; Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, 610041, China.
Redox Biol. 2024 Oct;76:103332. doi: 10.1016/j.redox.2024.103332. Epub 2024 Aug 30.
Reactive Oxygen Species (ROS) refer to a variety of derivatives of molecular oxygen that play crucial roles in regulating a wide range of physiological and pathological processes. Excessive ROS levels can cause oxidative stress, leading to cellular damage and even cell demise. However, moderately elevated levels of ROS can mediate the oxidative post-translational modifications (oxPTMs) of redox-sensitive proteins, thereby affecting protein functions and regulating various cellular signaling pathways. Among the oxPTMs, ROS-induced reversible protein sulfenylation represents the initial form of cysteine oxidation for sensing redox signaling. In this review, we will summarize the discovery, chemical formation, and detection approaches of protein sulfenylation. In addition, we will highlight recent findings for the roles of protein sulfenylation in various diseases, including thrombotic disorders, diabetes, cardiovascular diseases, neurodegenerative diseases, and cancer.
活性氧（ROS）是指分子氧的各种衍生物，在调节广泛的生理和病理过程中起着至关重要的作用。ROS 水平过高会导致氧化应激，导致细胞损伤甚至死亡。然而，适度升高的 ROS 可以介导氧化敏感蛋白的翻译后修饰（oxPTMs），从而影响蛋白质功能并调节各种细胞信号通路。在这些 oxPTMs 中，ROS 诱导的可逆蛋白质亚磺化是氧化还原信号感应中半胱氨酸氧化的初始形式。在这篇综述中，我们将总结蛋白质亚磺化的发现、化学形成和检测方法。此外，我们还将重点介绍蛋白质亚磺化在各种疾病中的作用的最新发现，包括血栓性疾病、糖尿病、心血管疾病、神经退行性疾病和癌症。
