膳食炎症指数和复合膳食抗氧化指数与美国成年人保留比受损肺活量之间的关联及甘油三酯-葡萄糖指数的中介作用：NHANES 2007-2012。

Associations of dietary inflammation index and composite dietary antioxidant index with preserved ratio impaired spirometry in US adults and the mediating roles of triglyceride-glucose index: NHANES 2007-2012.

机构信息

School of Public Health, Guangzhou Medical University, Xinzao, Panyu District, Guangzhou 511436, China.

出版信息

Redox Biol. 2024 Oct;76:103334. doi: 10.1016/j.redox.2024.103334. Epub 2024 Aug 30.

BACKGROUND

Previous studies have shown that inflammatory and antioxidant dietary patterns can modify the risk of COPD, yet few studies have examined the association of these diets with its early signs (PRISm), and the potential role of metabolic disorders remains to be elucidated.

METHODS

Data from 9529 individuals who participated in the 2007-2012 National Health and Nutrition Examination Survey (NHANES) were analyzed. The Dietary Inflammation Index (DII) and the Dietary Antioxidant Composite Index (CDAI) were assessed using 24-h dietary recall, multiple metabolic indicators were calculated according to biochemical markers, and lung function parameters defined PRISm cases. Individual and joint effects of DII and CDAI were evaluated by generalized linear models and binary logistic regression models, and mediation effects of metabolic indicators were further explored by causal mediation analysis.

RESULTS

Increased DII was associated with decreased lung function (FEV1: β = -18.82, FVC: β = -29.2; OR = 1.04) and increased metabolic indicators (β = 0.316, 0.036, 0.916, 0.033, and 0.145 on MAP, UA, TC, TyG, and MS, respectively). Contrary to this, CDAI were positively and negatively associated with lung function (FEV1: β = 3.42; FVC: β = 4.91; PRISm: OR = 0.99) and metabolic indicators (β < 0), respectively. Joint effects of DII and CDAI indicated the minimal hazard effects of DII on TyG (β = -0.11), FEV1 (β = 72.62), FVC (β = 122.27), and PRISm (OR = 0.79) in subjects with high CDAI when compared with those with low CDAI (low DII + high CDAI vs. high DII + low CDAI). Furthermore, TyG mediated 13.74 %, 8.29 %, and 21.70 % of DII- and 37.30 %, 20.90 %, and 12.32 % of CDAI-FEV1, -FVC, and -PRISm associations, respectively.

CONCLUSIONS

These findings indicated that CDAI can attenuate the adverse effects of DII on metabolic disorders and lung function decline, which provides new insight for diet modification in preventing early lung dysfunction.

背景

先前的研究表明，炎症和抗氧化的饮食模式可以改变 COPD 的风险，但很少有研究检测这些饮食模式与 COPD 的早期迹象（PRISm）之间的关系，而代谢紊乱的潜在作用仍有待阐明。

方法

分析了 9529 名参加 2007-2012 年全国健康和营养调查（NHANES）的个体的数据。采用 24 小时膳食回顾法评估膳食炎症指数（DII）和膳食抗氧化复合指数（CDAI），根据生化标志物计算多个代谢指标，根据肺功能参数定义 PRISm 病例。采用广义线性模型和二项逻辑回归模型评估 DII 和 CDAI 的个体和联合效应，并进一步通过因果中介分析探索代谢指标的中介效应。

结果

DII 升高与肺功能下降（FEV1：β=-18.82，FVC：β=-29.2；OR=1.04）和代谢指标升高有关（β=0.316、0.036、0.916、0.033 和 0.145，分别对应于 MAP、UA、TC、TyG 和 MS）。相反，CDAI 与肺功能（FEV1：β=3.42；FVC：β=4.91；PRISm：OR=0.99）和代谢指标呈正相关和负相关（β<0）。DII 和 CDAI 的联合效应表明，与低 CDAI 相比，高 CDAI 时 DII 对 TyG（β=-0.11）、FEV1（β=72.62）、FVC（β=122.27）和 PRISm（OR=0.79）的最小危害作用在 DII 较高的受试者中（低 DII+高 CDAI 与高 DII+低 CDAI 相比）。此外，TyG 介导了 DII 和 CDAI-FEV1、-FVC 和-PRISm 关联的 13.74%、8.29%和 21.70%、37.30%、20.90%和 12.32%。