Kim J P, D'Arpa P, Jacobson-Kram D, Williams J R
Mutat Res. 1985 May;149(3):437-42. doi: 10.1016/0027-5107(85)90161-7.
The dose-response relationship for mitomycin-C (MMC)-induced sister-chromatid exchange (SCE) has been determined in the progeny of Chinese hamster lung fibroblasts (V79) exposed to 5.0 J/m2 ultraviolet light-C (UVC, 254 nm) and in the progeny of non-UVC-irradiated controls. Progeny of UVC-irradiated cultures exhibited sensitivity to MMC-induced SCE at doses of MMC that were not detectably lethal. This sensitivity was manifest as an increase in SCE per cell in a large proportion of the cells derived from UVC-exposed cultures and thus appears not to result from the expression of a rare event such as mutation.
已在暴露于5.0 J/m²紫外线C（UVC，254 nm）的中国仓鼠肺成纤维细胞（V79）的子代以及未接受UVC照射的对照子代中确定了丝裂霉素C（MMC）诱导的姐妹染色单体交换（SCE）的剂量反应关系。UVC照射培养物的子代在MMC剂量未检测到致死性时，对MMC诱导的SCE表现出敏感性。这种敏感性表现为来自UVC暴露培养物的大部分细胞中每个细胞的SCE增加，因此似乎不是由罕见事件如突变的表达引起的。
