2022 年 ACR/EULAR 分类标准与抗中性粒细胞胞浆抗体相关性血管炎的欧洲药品管理局算法的比较性能。

Performance of the 2022 ACR/EULAR Classification Criteria in Comparison With the European Medicines Agency Algorithm in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis.

机构信息

Y. Imai, MD, K. Matsumoto, MD, PhD, M. Akiyama, MD, PhD, Y. Kaneko, MD, PhD, Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo.

Y. Ota, MD, Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, and Division of Rheumatology, Department of Internal Medicine, Tokai University School of Medicine, Kanagawa.

出版信息

J Rheumatol. 2024 Nov 1;51(11):1102-1110. doi: 10.3899/jrheum.2024-0335.

DOI:10.3899/jrheum.2024-0335

PMID:39218447

Abstract

OBJECTIVE

This study aimed to compare the 2022 American College of Rheumatology (ACR)/European Alliance of Associations for Rheumatology (EULAR) classification criteria with the European Medicines Agency (EMA) algorithm for antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV).

METHODS

All consecutive, newly diagnosed patients with AAV according to the 2012 Chapel Hill Consensus Conference who visited Keio University Hospital between March 2012 and May 2022 were retrospectively reviewed. Patients were reclassified according to the EMA algorithm and the 2022 ACR/EULAR criteria, and their clinical characteristics were statistically analyzed.

RESULTS

A total of 114 patients with AAV were included in the analyses. Using the EMA algorithm as a reference, reclassification of the patients revealed sensitivity and specificity of the 2022 ACR/EULAR criteria of 100% and 96% for eosinophilic granulomatosis with polyangiitis, 40% and 97% for granulomatosis with polyangiitis (GPA), and 90% and 49% for microscopic polyangiitis (MPA), respectively. Approximately half of patients classified as EMA-GPA or EMA-unclassifiable were reclassified as 2022-MPA; these patients were older, were more disposed to be positive for myeloperoxidase (MPO)-ANCA, and had interstitial lung disease (ILD) more frequently than patients with 2022-GPA or non-2022-MPA. Further, some patients positive for MPO-ANCA with biopsy-proven granulomatous inflammation were also reclassified from EMA-GPA to 2022-MPA. Over the mean observation period of 4.0 years, 16 patients died. Overall survival for each classification group differed significantly from the 2022 ACR/EULAR criteria ( = 0.02), but not with the EMA algorithm ( = 0.21).

CONCLUSION

Among the patients classified as EMA-GPA or EMA-unclassifiable, older patients with MPO-ANCA and ILD tended to be reclassified as 2022-MPA. The 2022 ACR/EULAR criteria were more useful in prognostic prediction than the EMA algorithm.

摘要

目的

本研究旨在比较 2022 年美国风湿病学会（ACR）/欧洲抗风湿病联盟（EULAR）分类标准与欧洲药品管理局（EMA）抗中性粒细胞胞浆抗体（ANCA）相关性血管炎（AAV）算法。

方法

回顾性分析 2012 年 3 月至 2022 年 5 月期间在庆应义塾大学医院就诊的所有符合 2012 年查尔希利共识会议定义的新诊断的 AAV 连续患者。根据 EMA 算法和 2022 年 ACR/EULAR 标准对患者进行重新分类，并对其临床特征进行统计学分析。

结果

共纳入 114 例 AAV 患者。以 EMA 算法为参考，患者的重新分类显示 2022 年 ACR/EULAR 标准对嗜酸性肉芽肿性多血管炎的敏感性和特异性分别为 100%和 96%，对肉芽肿性多血管炎（GPA）的敏感性和特异性分别为 40%和 97%，对显微镜下多血管炎（MPA）的敏感性和特异性分别为 90%和 49%。约一半被归类为 EMA-GPA 或 EMA 无法分类的患者被重新归类为 2022-MPA；这些患者年龄较大，更倾向于 MPO-ANCA 阳性，间质性肺病（ILD）更常见，与 2022-GPA 或非 2022-MPA 患者相比。此外，一些 MPO-ANCA 阳性且活检证实为肉芽肿性炎症的患者也从 EMA-GPA 重新归类为 2022-MPA。在平均 4.0 年的观察期内，16 名患者死亡。每个分类组的总生存率与 2022 年 ACR/EULAR 标准有显著差异（ = 0.02），但与 EMA 算法无显著差异（ = 0.21）。