Abdel Kulthum A, Kalluvya Samuel E, Sadiq Abid M, Ashir Abdel, Masikini Peter I
Department of Internal Medicine, Catholic University of Health and Allied Sciences, Mwanza, Tanzania.
Department of Internal Medicine, Bugando Medical Centre, Mwanza, Tanzania.
Clin Med Insights Endocrinol Diabetes. 2024 Aug 30;17:11795514241274694. doi: 10.1177/11795514241274694. eCollection 2024.
There has been increasing evidence of the association between hyperuricemia and diabetes mellitus (DM). In the general population, hyperuricemia has been associated with pre-diabetes. In DM patients, hyperuricemia has been associated with poor outcomes.
The objective was to determine the proportion of hyperuricemia and associated factors among patients with type 2 DM in Mwanza, Tanzania.
This was a cross-sectional study.
This study was conducted from January to March 2023 among patients with type 2 DM attending clinic at Bugando Medical Centre, Mwanza. Data was obtained from a structured questionnaire. Serum uric acid, HbA1c, lipid profile, and renal functions were analyzed. Analysis was done via STATA version 17. The primary outcome was the proportion of hyperuricemia among patients with type 2 DM, and logistic regression models were used to analyze associated factors.
Out of 360 patients, 59.7% were female. The median age was 61 years [IQR 57-68], and the median duration of DM was 5 years [IQR 3-9]. The mean HbA1c was 8.2 ± 2.5%, with 60% of patients having poor control. Most patients had hypertension (78.9%) and were overweight or obese (81.9%). The proportion of patients with DM and hyperuricemia was 44.4%, with mean serum uric acid levels among males and females of 410 ± 137 and 385 ± 119 µmol/L, respectively. We found that being female (P = .001), overweight (P = .021), or obese (P = .007), and having chronic kidney disease (P < .001) was associated with hyperuricemia among patients with type 2 DM.
The burden of hyperuricemia among type 2 DM patients is quite high, and it is associated with female gender, high body mass index, lipids, and chronic kidney disease. This calls for regular screening of hyperuricemia in the population, and more studies are needed to establish the outcomes associated with hyperuricemia and create a treatment guideline.
越来越多的证据表明高尿酸血症与糖尿病（DM）之间存在关联。在普通人群中，高尿酸血症与糖尿病前期有关。在糖尿病患者中，高尿酸血症与不良预后有关。
确定坦桑尼亚姆万扎2型糖尿病患者中高尿酸血症的比例及相关因素。
这是一项横断面研究。
本研究于2023年1月至3月在姆万扎布甘多医疗中心就诊的2型糖尿病患者中进行。数据通过结构化问卷获得。分析血清尿酸、糖化血红蛋白（HbA1c）、血脂谱和肾功能。使用STATA 17版本进行分析。主要结果是2型糖尿病患者中高尿酸血症的比例，并使用逻辑回归模型分析相关因素。
360名患者中，59.7%为女性。中位年龄为61岁[四分位间距（IQR）57 - 68]，糖尿病中位病程为5年[IQR 3 - 9]。平均糖化血红蛋白为8.2±2.5%，60%的患者控制不佳。大多数患者患有高血压（78.9%），超重或肥胖（81.9%）。糖尿病合并高尿酸血症患者的比例为44.4%，男性和女性的平均血清尿酸水平分别为410±137和385±119µmol/L。我们发现，女性（P = 0.001）、超重（P = 0.021）或肥胖（P = 0.007）以及患有慢性肾脏病（P < 0.001）与2型糖尿病患者的高尿酸血症有关。
2型糖尿病患者中高尿酸血症的负担相当高，并且与女性性别、高体重指数、血脂和慢性肾脏病有关。这就要求对人群进行高尿酸血症的定期筛查，并且需要更多研究来确定与高尿酸血症相关的预后情况并制定治疗指南。
