Arersa Kumsa Kene, Wondimnew Tesaka, Welde Mengistu, Husen Tigist Mateos
Department of Biomedical Sciences, Division of Biochemistry, Jimma University, Institute of Health Sciences, Jimma, Ethiopia.
Diabetes Metab Syndr Obes. 2020 Jun 18;13:2059-2067. doi: 10.2147/DMSO.S252825. eCollection 2020.
To assess the prevalence and determinants of hyperuricemia among type 2 diabetic patients on follow-up at Jimma Medical Center from March 1 to June 30, 2019.
This institution-based cross-sectional study was used to assess the level of serum uric acid in type 2 diabetic patients attending their follow-up at Jimma Medical Center chronic illness clinic. A systematic sampling technique was used to include 287 type 2 diabetic patients in the study and an interviewer-based questionnaire was used to collect important data from each participant. Five milliliters of blood were collected from each participant under sterile conditions and serum was separated by centrifugation at 3000 rpm for 10 minutes. Serum was stored at -20°C and analyzed for serum uric acid using an ABX Pentra 400 clinical chemistry analyzer. Bivariate and multivariable binary logistic regression were used to assess significant associations between hyperuricemia and independent factors. A -value of <0.05 was considered significant in the final model.
The mean±SD age of the study participants was 51.79±14.36 years. The prevalence of hyperuricemia was found to be 22% (n=66/287) in the study population. Hyperuricemia was common in those aged ≥60 years and males. Obesity (AOR=7.84, 95% CI=2.005-30.666), duration of diabetes mellitus (DM) ≥10 years (AOR=3.963, 95% CI=1.902-8.259), family history of CVD (AOR=2.929, 95% CI=1.124-7.630), alcohol drinking (AOR=5.83, 95% CI=2.341-14.545) and increased DBP (AOR=4.198, 95% CI=1.772-9.949) were determinant variables for hyperuricemia in type 2 DM.
Hyperuricemia was relatively common among type 2 diabetic patients. The prevalence of hyperuricemia was common among patients with obesity, a long duration of DM and increased diastolic blood pressure, and alcohol drinkers. There is a need to raise awareness of lifestyle modification, healthy behavior and early diagnosis of hyperuricemia in type 2 diabetic patients.
评估2019年3月1日至6月30日在吉马医疗中心接受随访的2型糖尿病患者高尿酸血症的患病率及其决定因素。
本基于机构的横断面研究用于评估在吉马医疗中心慢性病门诊接受随访的2型糖尿病患者的血清尿酸水平。采用系统抽样技术纳入287例2型糖尿病患者进行研究，并使用基于访谈的问卷收集每位参与者的重要数据。在无菌条件下从每位参与者采集5毫升血液，以3000转/分钟的速度离心10分钟分离血清。血清储存在-20°C，使用ABX Pentra 400临床化学分析仪分析血清尿酸。采用双变量和多变量二元逻辑回归评估高尿酸血症与独立因素之间的显著关联。最终模型中P值<0.05被认为具有显著性。
研究参与者的平均年龄±标准差为51.79±14.36岁。研究人群中高尿酸血症的患病率为22%（n = 66/287）。高尿酸血症在≥60岁的人群和男性中较为常见。肥胖（比值比[AOR]=7.84，95%置信区间[CI]=2.005 - 30.666）、糖尿病（DM）病程≥10年（AOR = 3.963，95% CI = 1.902 - 8.259）、心血管疾病（CVD）家族史（AOR = 2.929，95% CI = 1.124 - 7.630）、饮酒（AOR = 5.83，95% CI = 2.341 - 14.545）和舒张压升高（AOR = 4.198，95% CI = 1.772 - 9.949）是2型糖尿病患者高尿酸血症的决定变量。
高尿酸血症在2型糖尿病患者中相对常见。高尿酸血症在肥胖、糖尿病病程长、舒张压升高的患者以及饮酒者中较为普遍。有必要提高对2型糖尿病患者生活方式改变、健康行为和高尿酸血症早期诊断的认识。
