Gong Min, Wen Song, Nguyen Thiquynhnga, Wang Chaoxun, Jin Jianlan, Zhou Ligang
Department of Endocrinology, Shanghai Pudong Hospital, Fudan University, Shanghai 201399, People's Republic of China.
Diabetes Metab Syndr Obes. 2020 Mar 30;13:943-962. doi: 10.2147/DMSO.S232377. eCollection 2020.
Obesity and hyperuricemia mutually influence metabolic syndrome. This study discusses the metabolic relationships between obesity and hyperuricemia in terms of pathophysiology, complications, and treatments.
We searched for preclinical or clinical studies on the pathophysiology, complications, and therapy of obesity and hyperuricemia on the PubMed database.
In this systemic review, we summarized our searching results on topics of pathophysiology, complications and therapeutic strategy. In pathophysiology, we firstly introduce genetic variations for obesity, hyperuricemia and their relationships by genetic studies. Secondly, we talk about the epigenetic influences on obesity and hyperuricemia. Thirdly, we describe the central metabolic regulation and the role of hyperuricemia. Then, we refer to the character of adipose tissue inflammation and oxidative stress in the obesity and hyperuricemia. In the last part of this topic, we reviewed the critical links of gut microbiota in the obesity and hyperuricemia. In the following part, we review the pathophysiology of major complications in obesity and hyperuricemia including insulin resistance and type 2 diabetes mellitus, chronic kidney disease, cardiovascular diseases, and cancers. Finally, we recapitulate the therapeutic strategies especially the novel pharmaceutic interventions for obesity and hyperuricemia, which concurrently show the mutual metabolic influences between two diseases.
The data reviewed here delineate the metabolic relationships between obesity and hyperuricemia, and provide a comprehensive overview of the therapeutic targets for the management of metabolic syndromes.
肥胖与高尿酸血症相互影响代谢综合征。本研究从病理生理学、并发症及治疗方面探讨肥胖与高尿酸血症之间的代谢关系。
我们在PubMed数据库中检索了关于肥胖与高尿酸血症的病理生理学、并发症及治疗的临床前或临床研究。
在本系统评价中，我们总结了关于病理生理学、并发症及治疗策略等主题的检索结果。在病理生理学方面，我们首先通过遗传学研究介绍肥胖、高尿酸血症的基因变异及其关系。其次，我们讨论表观遗传学对肥胖和高尿酸血症的影响。第三，我们描述中枢代谢调节及高尿酸血症的作用。然后，我们提及肥胖和高尿酸血症中脂肪组织炎症和氧化应激的特征。在本主题的最后部分，我们综述了肠道微生物群在肥胖和高尿酸血症中的关键联系。在接下来的部分，我们综述肥胖和高尿酸血症主要并发症的病理生理学，包括胰岛素抵抗和2型糖尿病、慢性肾脏病、心血管疾病及癌症。最后，我们概括治疗策略，尤其是针对肥胖和高尿酸血症的新型药物干预措施，这些措施同时显示了两种疾病之间的相互代谢影响。
本文回顾的数据描绘了肥胖与高尿酸血症之间的代谢关系，并为代谢综合征管理的治疗靶点提供了全面概述。
