van Schouwenburg J A, Kruger T F
S Afr Med J. 1985 May 11;67(19):759-61.
Two different protocols for ovulation induction used in phase I of the in vitro fertilization (IVF) programme at Tygerberg Hospital are presented. Previous experience with gonadotrophins and clomiphene citrate was applied in the development of the protocols. By means of experience gained during ovulation induction it was possible to establish critical values for the parameters of follicle maturity, which are used to determine the optimal time for follicle aspiration. Ultrasonically measured follicle size, critical serum oestradiol levels for each mature follicle and cervical mucus scoring were the parameters used. Fifty-one ova were obtained during 29 of the 34 attempts at follicle aspiration. Only 5 of the ova were immature. At least 1 mature ovum was obtained at 80% of all laparoscopies. Twenty-three embryos were transferred to 15 patients, and 3 pregnancies occurred. As a result of this programme 2 babies were born--the first in South Africa by IVF and embryo transfer.
本文介绍了泰格堡医院体外受精（IVF）计划第一阶段使用的两种不同的促排卵方案。在方案制定过程中借鉴了以往使用促性腺激素和枸橼酸氯米芬的经验。通过促排卵过程中积累的经验，得以确定卵泡成熟参数的临界值，这些参数用于确定卵泡抽吸的最佳时间。所使用的参数包括超声测量的卵泡大小、每个成熟卵泡的临界血清雌二醇水平和宫颈黏液评分。在34次卵泡抽吸尝试中的29次获得了51个卵子。其中只有5个卵子不成熟。在所有腹腔镜检查中，80%至少获得了1个成熟卵子。将23个胚胎移植给了15名患者，发生了3次妊娠。由于该计划，诞生了2名婴儿——这是南非首例通过体外受精和胚胎移植出生的婴儿。
