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Can Targeting the Sodium Site via Water Molecules Lead to the Development of Safer Opioids?

作者信息

Wacker Daniel, Filizola Marta

机构信息

Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029-6574, United States.

出版信息

ACS Cent Sci. 2024 Aug 8;10(8):1436-1438. doi: 10.1021/acscentsci.4c01105. eCollection 2024 Aug 28.

DOI:10.1021/acscentsci.4c01105
PMID:39220703
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11363340/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6a0/11363340/77fb62ee9368/oc4c01105_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6a0/11363340/77fb62ee9368/oc4c01105_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6a0/11363340/77fb62ee9368/oc4c01105_0001.jpg

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Expert Rev Clin Pharmacol. 2023 Jan-Jun;16(6):589-599. doi: 10.1080/17512433.2023.2213889. Epub 2023 May 15.
2
Structure-based design of bitopic ligands for the µ-opioid receptor.基于结构的μ-阿片受体双位点配体设计。
Nature. 2023 Jan;613(7945):767-774. doi: 10.1038/s41586-022-05588-y. Epub 2022 Nov 30.
3
A Regional and Projection-Specific Role of RGSz1 in the Ventrolateral Periaqueductal Grey in the Modulation of Morphine Reward.
RGSz1 在腹外侧脑桥导水管周围灰质中对吗啡奖赏的区域性和投射特异性调节作用。
Mol Pharmacol. 2023 Jan;103(1):1-8. doi: 10.1124/molpharm.122.000528. Epub 2022 Oct 30.
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Low intrinsic efficacy for G protein activation can explain the improved side effect profiles of new opioid agonists.对G蛋白激活的内在效力较低可以解释新型阿片类激动剂改善的副作用情况。
Sci Signal. 2020 Mar 31;13(625):eaaz3140. doi: 10.1126/scisignal.aaz3140.
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Kinetic and thermodynamic insights into sodium ion translocation through the μ-opioid receptor from molecular dynamics and machine learning analysis.从分子动力学和机器学习分析中深入了解钠离子通过μ-阿片受体的迁移:动力学和热力学见解。
PLoS Comput Biol. 2019 Jan 24;15(1):e1006689. doi: 10.1371/journal.pcbi.1006689. eCollection 2019 Jan.
6
Untangling the complexity of opioid receptor function.解析阿片受体功能的复杂性。
Neuropsychopharmacology. 2018 Dec;43(13):2514-2520. doi: 10.1038/s41386-018-0225-3. Epub 2018 Sep 24.
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