Department of Biosciences and Biomedical Engineering, Indian Institute of Technology, Indore, Khandwa Road, Simrol, Indore - 453552, Madhya Pradesh, India.
Analyst. 2024 Sep 23;149(19):4811-4829. doi: 10.1039/d4an00806e.
Globally, the primary causes of mortality and morbidity related to kidney ailments can be classified as Acute Kidney Injury (AKI) and Chronic Kidney Disease (CKD). Biomarker detection can have great potential to improve survival, lower mortality, and reduce the cost of treatment of kidney diseases. Considering the chronic nature of CKD, non-invasive identification and monitoring have proven to be useful. Biosensors and more specifically lateral flow test strips (LFTs) are regarded as the most desirable point-of-care instruments which have shown promise in elevating the healthcare industry to a new level. The major aspects of an ideal point-of-care (POC) lateral flow test include its cost effectiveness, high sensitivity and specificity, ease of use, quick result delivery, and quality control. This review provides a detailed account of recent developments, challenges, and opportunities in renal biomarker detection using LFTs including various approaches for sensitivity enhancement along with potential future advancements in POC and LFT kits.
在全球范围内，与肾脏疾病相关的主要死亡和发病原因可分为急性肾损伤 (AKI) 和慢性肾脏病 (CKD)。生物标志物检测具有提高生存率、降低死亡率和降低肾脏疾病治疗成本的巨大潜力。鉴于 CKD 的慢性性质，非侵入性识别和监测已被证明是有用的。生物传感器，特别是横向流动测试条 (LFT)，被认为是最理想的即时检测仪器，它们有望将医疗保健行业提升到一个新的水平。理想的即时检测 (POC) 横向流动测试的主要方面包括其成本效益、高灵敏度和特异性、易用性、快速结果交付和质量控制。本综述详细介绍了使用 LFT 进行肾脏生物标志物检测的最新进展、挑战和机遇，包括各种提高灵敏度的方法，以及 POC 和 LFT 试剂盒的潜在未来发展。
