Qiu Dayong, Zhang Yan, Ni Pinshi, Wang Zhuangzhi, Yang Luodan, Li Fanghui
School of Physical and Health Education, Nanjing Normal University Taizhou College, No. 96, Jichuan East Road, Hailing District, Taizhou, 225300, P.R. China.
School of Sport Sciences, Nanjing Normal University, No. 1 Wenyuan Road, Qixia District, Nanjing, 210046, P.R. China.
J Physiol Biochem. 2024 Nov;80(4):795-809. doi: 10.1007/s13105-024-01043-w. Epub 2024 Sep 2.
The objectives of this review were to understand the impact of microRNA-486 on myogenesis and muscle atrophy, and the change of microRNA-486 following exercise, and provide valuable information for improving muscle atrophy based on exercise intervention targeting microRNA-486. Muscle-enriched microRNAs (miRNAs), also referred to as myomiRs, control various processes in skeletal muscles, from myogenesis and muscle homeostasis to different responses to environmental stimuli such as exercise. MicroRNA-486 is a miRNA in which a stem-loop sequence is embedded within the ANKYRIN1 (ANK1) locus and is strictly conserved across mammals. MicroRNA-486 is involved in the development of muscle atrophy caused by aging, immobility, prolonged exposure to microgravity, or muscular and neuromuscular disorders. PI3K/AKT signaling is a positive pathway, as it increases muscle mass by increasing protein synthesis and decreasing protein degradation. MicroRNA-486 can activate this pathway by inhibiting phosphatase and tensin homolog (PTEN), it may also indirectly inhibit the HIPPO signaling pathway to promote cell growth. Exercises regulate microRNA-486 expression both in blood and muscle. This review focused on the recent elucidation of sarcopenia regulation by microRNA-486 and its effects on pathological states, including primary muscular disease, secondary muscular disorders, and age-related sarcopenia. Additionally, the role of exercise in regulating skeletal muscle-enriched microRNA-486 was highlighted, along with its physiological significance. Growing evidence indicates that microRNA-486 significantly impacts the development of muscle atrophy. MicroRNA-486 has great potential to become a therapeutic target for improving muscle atrophy through exercise intervention.
本综述的目的是了解微小RNA - 486对肌肉生成和肌肉萎缩的影响，以及运动后微小RNA - 486的变化，并为基于针对微小RNA - 486的运动干预改善肌肉萎缩提供有价值的信息。肌肉富集的微小RNA（miRNA），也称为肌微小RNA，控制骨骼肌中的各种过程，从肌肉生成和肌肉稳态到对运动等环境刺激的不同反应。微小RNA - 486是一种微小RNA，其茎环序列嵌入锚蛋白1（ANK1）基因座内，在哺乳动物中严格保守。微小RNA - 486参与由衰老、固定不动、长期暴露于微重力或肌肉和神经肌肉疾病引起的肌肉萎缩的发展。PI3K/AKT信号通路是一条正向通路，因为它通过增加蛋白质合成和减少蛋白质降解来增加肌肉质量。微小RNA - 486可以通过抑制磷酸酶和张力蛋白同源物（PTEN）来激活该通路，它也可能间接抑制HIPPO信号通路以促进细胞生长。运动可调节血液和肌肉中微小RNA - 486的表达。本综述重点关注了微小RNA - 486对肌肉减少症调节的最新阐释及其对病理状态的影响，包括原发性肌肉疾病、继发性肌肉疾病和与年龄相关的肌肉减少症。此外，还强调了运动在调节骨骼肌富集的微小RNA - 486中的作用及其生理意义。越来越多的证据表明，微小RNA - 486对肌肉萎缩的发展有显著影响。微小RNA - 486极有可能成为通过运动干预改善肌肉萎缩的治疗靶点。
